Roles of specific membrane lipid domains in EGF receptor activation and cell adhesion molecule stabilization in a developing olfactory system.
Roles of specific membrane lipid domains in EGF receptor activation and cell adhesion molecule stabilization in a developing olfactory system.
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DOI：
10.1371/journal.pone.0007222
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发表时间：
2009-09-29
期刊：
影响因子：
3.7
通讯作者：
Oland LA
中科院分区：
文献类型：
--
作者：
Gibson NJ;Tolbert LP;Oland LA
Reciprocal interactions between glial cells and olfactory receptor neurons (ORNs) cause ORN axons entering the brain to sort, to fasciculate into bundles destined for specific glomeruli, and to form stable protoglomeruli in the developing olfactory system of an experimentally advantageous animal species, the moth Manduca sexta. Epidermal growth factor receptors (EGFRs) and the cell adhesion molecules (IgCAMs) neuroglian and fasciclin II are known to be important players in these processes. We report in situ and cell-culture studies that suggest a role for glycosphingolipid-rich membrane subdomains in neuron-glia interactions. Disruption of these subdomains by the use of methyl-β-cyclodextrin results in loss of EGFR activation, depletion of fasciclin II in ORN axons, and loss of neuroglian stabilization in the membrane. At the cellular level, disruption leads to aberrant ORN axon trajectories, small antennal lobes, abnormal arrays of olfactory glomerul, and loss of normal glial cell migration. We propose that glycosphingolipid-rich membrane subdomains (possible membrane rafts or platforms) are essential for IgCAM-mediated EGFR activation and for anchoring of neuroglian to the cytoskeleton, both required for normal extension and sorting of ORN axons.
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影响因子：
4.8
作者：
Biscardi, JS;Maa, MC;Parsons, SJ
通讯作者：
Parsons, SJ
DOI：
10.1083/jcb.200111076
发表时间：
2002-06-24
期刊：
The Journal of cell biology
影响因子：
--
作者：
Dickson TC;Mintz CD;Benson DL;Salton SR
通讯作者：
Salton SR
DOI：
10.1073/pnas.95.20.12022
发表时间：
1998-09-29
影响因子：
11.1
作者：
Fry, DW;Bridges, AJ;Dobrusin, EM
通讯作者：
Dobrusin, EM
影响因子：
16.2
作者：
García-Alonso, L;Romani, S;Jiménez, F
通讯作者：
Jiménez, F
影响因子：
3.9
作者：
Bazley, LA;Gullick, WJ
通讯作者：
Gullick, WJ