Intracranial Pressure Monitoring In Nontraumatic Intraventricular Hemorrhage Rodent Model.
Intracranial Pressure Monitoring In Nontraumatic Intraventricular Hemorrhage Rodent Model.
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DOI：
10.3791/63309
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发表时间：
2022-02-08
影响因子：
1.2
通讯作者：
Waldau, Ben
中科院分区：
文献类型：
--
作者：
Peterson, Catherine;Hawk, Cameron;Puglisi, Chloe H.;Waldau, Ben
脑室内出血的幸存者通常会留下严重的长期记忆障碍；因此，利用脑室内出血动物模型进行研究是必要的。在这项研究中，我们寻找了测量啮齿类动物非外伤性脑室内出血期间的颅内压、平均动脉压和脑灌注压的方法。实验设计分为3个Sprague Dawley组：假手术组、标准200 μl脑室内出血组和载药对照组。通过引入脑实质内光纤压力传感器，所有组均获得精确的颅内压测量。根据颅内压和平均动脉压值计算脑灌注压。不出所料，脑室内出血组和对照组分别在脑室内注射自体血和人工脑脊液时颅内压升高，随后脑灌注压下降。添加肺实质内光纤压力传感器有利于精确监测颅内压变化。
Survivors of intraventricular hemorrhage are often left with significant long-term memory impairment; thus, research utilizing intraventricular hemorrhage animal models is essential. In this study, we sought out ways to measure intracranial pressure, mean arterial pressure, and cerebral perfusion pressure during nontraumatic intraventricular hemorrhage in rodents. The experimental design included three Sprague Dawley groups: sham, standard 200 μl intraventricular hemorrhage, and vehicle control groups. By introducing an intraparenchymal fiberoptic pressure sensor, precise intracranial pressure measurements were obtained in all groups. Cerebral perfusion pressures were calculated with the knowledge of intracranial pressure and mean arterial pressure values. As expected, the intraventricular hemorrhage and vehicle control groups both experienced a rise in the intracranial pressure and subsequent decline in cerebral perfusion pressure during intraventricular injection of autologous blood and artificial cerebrospinal fluid, respectively. The addition of an intraparenchymal fiberoptic pressure sensor is beneficial in monitoring precise intracranial pressure changes.
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影响因子：
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