Mechanisms of hydrocephalus after neonatal and adult intraventricular hemorrhage.
Mechanisms of hydrocephalus after neonatal and adult intraventricular hemorrhage.
复制标题
新生儿和成年脑室内出血后的脑积水机制。
DOI：
10.1007/s12975-012-0182-9
复制
发表时间：
2012-07
影响因子：
6.9
通讯作者：
Xi, Guohua
中科院分区：
文献类型：
--
作者：
Strahle, Jennifer;Garton, Hugh J. L.;Maher, Cormac O.;Muraszko, Karin M.;Keep, Richard F.;Xi, Guohua
脑室内出血（IVH）是一个重要的发病率和死亡率的原因，是脑出血（ICH）和老年基质出血（GMH）预后不良的独立预测因子。IVH可能导致脑损伤和脑积水。本文综述了IVH引起脑积水的机制和可能的治疗方法。一个经常被引用的解释IVH后脑积水的理论涉及微血栓闭塞蛛网膜绒毛，随后的炎症和纤维化导致CSF流出道阻塞。虽然有一些证据支持这一理论，但可能涉及其他机制，这些机制有助于脑积水的发展。目前还不清楚出血后急性和慢性脑积水的原因是否是通过不同的机制发生的;前者是血液的机械阻塞，后者是炎症和纤维化。IVH的管理和预防脑损伤和脑积水的策略是需要进一步研究的领域。更好地了解IVH后脑积水的发病机制，可能会导致改进的策略，以预防和治疗出血后脑积水。
Intraventricular hemorrhage (IVH) is a cause of significant morbidity and mortality and is an independent predictor of a worse outcome in intracerebral hemorrhage (ICH) and germinal matrix hemorrhage (GMH). IVH may result in both injuries to the brain as well as hydrocephalus. This paper reviews evidence on the mechanisms and potential treatments for IVH-induced hydrocephalus. One frequently cited theory to explain hydrocephalus after IVH involves obliteration of the arachnoid villi by microthrombi with subsequent inflammation and fibrosis causing CSF outflow obstruction. Although there is some evidence to support this theory, there may be other mechanisms involved, which contribute to the development of hydrocephalus. It is also unclear whether the causes of acute and chronic hydrocephalus after hemorrhage occur via different mechanisms; mechanical obstruction by blood in the former, and inflammation and fibrosis in the latter. Management of IVH and strategies for prevention of brain injury and hydrocephalus are areas requiring further study. A better understanding of the pathogenesis of hydrocephalus after IVH, may lead to improved strategies to prevent and treat post-hemorrhagic hydrocephalus.
登录
查看更多内容
影响因子：
5.1
作者：
Carlo, Waldemar A.;McDonald, Scott A.;Tyson, Jon E.;Stoll, Barbara J.;Ehrenkranz, Richard A.;Shankaran, Seetha;Goldberg, Ronald N.;Das, Abhik;Schendel, Diana;Thorsen, Poul;Skogstrand, Kristin;Hougaard, David M.;Oh, William;Laptook, Abbot R.;Duara, Shahnaz;Fanaroff, Avroy A.;Donovan, Edward F.;Korones, Sheldon B.;Stevenson, David K.;Papile, Lu-Ann;Finer, Neil N.;O'Shea, T. Michael;Poindexter, Brenda B.;Wright, Linda L.;Ambalavanan, Namasivayam;Higgins, Rosemary D.
通讯作者：
Higgins, Rosemary D.
DOI：
10.1152/ajpregu.1998.275.3.r889
发表时间：
1998-09-01
影响因子：
2.8
作者：
Boulton, M;Armstrong, D;Johnston, M
通讯作者：
Johnston, M
影响因子：
4.6
作者：
Banizs, B;Pike, MM;Yoder, BK
通讯作者：
Yoder, BK
影响因子：
2.1
作者：
Bassan, Haim
通讯作者：
Bassan, Haim
影响因子：
9
作者：
Dandy, WE
通讯作者：
Dandy, WE