Distinct functional networks within the cerebellum and their relation to cortical systems assessed with independent component analysis.
Distinct functional networks within the cerebellum and their relation to cortical systems assessed with independent component analysis.
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DOI：
10.1016/j.neuroimage.2012.01.139
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发表时间：
2012-05-01
期刊：
影响因子：
5.7
通讯作者：
McGlinchey, Regina E.
中科院分区：
文献类型：
--
作者：
Dobromyslin, Vitaly I.;Salat, David H.;Fortier, Catherine B.;Leritz, Elizabeth C.;Beckmann, Christian F.;Milberg, William P.;McGlinchey, Regina E.
小脑功能电路已被检查在几个先前的研究使用静息功能磁共振成像数据和种子为基础的程序，以及全脑独立成分分析（伊卡）。在这里，我们假设伊卡应用于小脑的功能数据专门将提供检测小脑网络的灵敏度比以前的方法。在两个年龄和性别相匹配的25名受试者中评估了组级网络的一致性。将仅小脑伊卡与传统的全脑伊卡程序进行比较，以检查新方法的灵敏度的潜在增益。除了复制一些以前确定的小脑网络，目前的方法揭示了至少一个网络组件，这是不明显的应用全脑伊卡。这些结果表明，通过指定小脑作为目标结构方面的鲁棒性和可靠的网络识别所获得的灵敏度的增益。使用类似的程序可能是重要的，在进一步扩大以前定义的小脑功能解剖模式，以及提供有关独特的网络，尚未在以前的工作中探索的信息。这些信息可能对理解小脑在健康和疾病中的认知和行为重要性至关重要。
Cerebellar functional circuitry has been examined in several prior studies using resting fMRI data and seed-based procedures, as well as whole-brain independent component analysis (ICA). Here, we hypothesized that ICA applied to functional data from the cerebellum exclusively would provide increased sensitivity for detecting cerebellar networks compared to previous approaches. Consistency of group-level networks was assessed in two age- and sex-matched groups of twenty-five subjects each. Cerebellum-only ICA was compared to the traditional whole-brain ICA procedure to examine the potential gain in sensitivity of the novel method. In addition to replicating a number of previously identified cerebellar networks, the current approach revealed at least one network component that was not apparent with the application of whole brain ICA. These results demonstrate the gain in sensitivity attained through specifying the cerebellum as a target structure with regard to the identification of robust and reliable networks. The use of similar procedures could be important in further expanding on previously defined patterns of cerebellar functional anatomy, as well as provide information about unique networks that have not been explored in prior work. Such information may prove crucial for understanding the cognitive and behavioral importance of the cerebellum in health and disease.
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DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
Beckmann, CF;DeLuca, M;Smith, SM
通讯作者：
Smith, SM
影响因子：
5.7
作者：
Beckmann, CF;Smith, SM
通讯作者：
Smith, SM
DOI：
10.1111/j.1749-6632.2002.tb07576.x
发表时间：
2002-01-01
期刊：
CREBELLUM: RECENT DEVELOPMENTS IN CEREBELLAR RESEARCH
影响因子：
--
作者：
Ivry, RB;Spencer, RM;Diedrichsen, J
通讯作者：
Diedrichsen, J
影响因子：
5.7
作者：
Diedrichsen, Joern;Balsters, Joshua H.;Ramnani, Narender
通讯作者：
Ramnani, Narender
DOI：
10.1073/pnas.0601417103
发表时间：
2006-09-12
影响因子：
11.1
作者：
Damoiseaux, J. S.;Rombouts, S. A. R. B.;Beckmann, C. F.
通讯作者：
Beckmann, C. F.