Photocontrolled nanoparticles for on-demand release of proteins.
Photocontrolled nanoparticles for on-demand release of proteins.
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DOI：
10.1021/bm300646q
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发表时间：
2012-08-13
影响因子：
6.2
通讯作者：
Anseth, Kristi S.
中科院分区：
文献类型：
--
作者：
Azagarsamy, Malar A.;Alge, Daniel L.;Radhakrishnan, Srinidhi J.;Tibbitt, Mark W.;Anseth, Kristi S.
We describe here light-regulated swelling and degradation features of polymeric nanoparticles that are produced using an inverse microemulsion polymerization method. We demonstrate the phototriggered release characteristics of the nanoparticles by sequestering protein molecules and releasing them using light as a trigger. Furthermore, the intracellular translocation of the nanoparticles, along with its fluorescent protein payload, was achieved using a cell-penetrating peptide-based surface modification. We expect that the noncovalent encapsulation of proteins using nanoparticles and their photo triggered release using an external light would provide opportunities for achieving intracellular release of molecular therapeutics for on-demand requirements.
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影响因子：
3.4
作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
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DOI：
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发表时间：
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通讯作者：
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影响因子：
15
作者：
Fomina, Nadezda;McFearin, Cathryn;Sermsakdi, Marleen;Edigin, Osayimwense;Almutairi, Adah
通讯作者：
Almutairi, Adah