Influenza vaccine effectiveness in the United States during 2012-2013: variable protection by age and virus type.
Influenza vaccine effectiveness in the United States during 2012-2013: variable protection by age and virus type.
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DOI：
10.1093/infdis/jiu647
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发表时间：
2015-05-15
期刊：
影响因子：
--
通讯作者：
Belongia EA
中科院分区：
文献类型：
--
作者：
McLean HQ;Thompson MG;Sundaram ME;Kieke BA;Gaglani M;Murthy K;Piedra PA;Zimmerman RK;Nowalk MP;Raviotta JM;Jackson ML;Jackson L;Ohmit SE;Petrie JG;Monto AS;Meece JK;Thaker SN;Clippard JR;Spencer SM;Fry AM;Belongia EA
背景：在2012-2013年流感季节，美国出现了甲型流感（H3 N2）和2种流感B谱系病毒的共同传播。 方法：前瞻性入选急性咳嗽疾病≤7天的患者，并在5个州的门诊获得拭子样本。 通过病历确认流感疫苗接种日期。病例与检测阴性对照相比，疫苗接种的疫苗有效性（VE）估计为[100% ×（1 −调整比值比）]。结果：在6452名患者中有2307名（36%）检测到流感; 1292名（56%）为甲型流感（H3 N2），582名（25%）为B/Yamagata，303名（13%）为B/维多利亚。 总体VE为49%（95%置信区间[CI]，43%-55%），甲型流感（H3 N2）为39%（95% CI，29%-47%），乙型流感B/Yamagata（疫苗谱系）为66%（95% CI，58%-73%），乙型流感B/维多利亚为51%（95% CI，36%-63%）。50-64岁人群（52%; 95% CI，33%-65%）和6个月-8岁人群（51%; 95% CI，32%-64%）的抗甲型流感（H3 N2）VE最高，≥65岁人群最低（11%; 95% CI，−41%-43%）。在较年轻的年龄组中，有证据表明1年前接受2011-2012年疫苗的剩余保护。结论：2012-2013年的疫苗在大多数年龄组中是中等有效的。 观察到交叉谱系保护和既往疫苗接种的残留效应，需要进一步研究。
Background. During the 2012–2013 influenza season, there was cocirculation of influenza A(H3N2) and 2 influenza B lineage viruses in the United States. Methods. Patients with acute cough illness for ≤7 days were prospectively enrolled and had swab samples obtained at outpatient clinics in 5 states. Influenza vaccination dates were confirmed by medical records. The vaccine effectiveness (VE) was estimated as [100% × (1 − adjusted odds ratio)] for vaccination in cases versus test-negative controls. Results. Influenza was detected in 2307 of 6452 patients (36%); 1292 (56%) had influenza A(H3N2), 582 (25%) had influenza B/Yamagata, and 303 (13%) had influenza B/Victoria. VE was 49% (95% confidence interval [CI], 43%–55%) overall, 39% (95% CI, 29%–47%) against influenza A(H3N2), 66% (95% CI, 58%–73%) against influenza B/Yamagata (vaccine lineage), and 51% (95% CI, 36%–63%) against influenza B/Victoria. VE against influenza A(H3N2) was highest among persons aged 50–64 years (52%; 95% CI, 33%–65%) and persons aged 6 months–8 years (51%; 95% CI, 32%–64%) and lowest among persons aged ≥65 years (11%; 95% CI, −41% to 43%). In younger age groups, there was evidence of residual protection from receipt of the 2011–2012 vaccine 1 year earlier. Conclusions. The 2012–2013 vaccines were moderately effective in most age groups. Cross-lineage protection and residual effects from prior vaccination were observed and warrant further investigation.
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影响因子：
3.7
作者：
Skowronski DM;Janjua NZ;De Serres G;Sabaiduc S;Eshaghi A;Dickinson JA;Fonseca K;Winter AL;Gubbay JB;Krajden M;Petric M;Charest H;Bastien N;Kwindt TL;Mahmud SM;Van Caeseele P;Li Y
通讯作者：
Li Y
影响因子：
11.8
作者：
Treanor, John J.;Talbot, H. Keipp;Shay, David K.
通讯作者：
Shay, David K.
影响因子：
5.5
作者：
Foppa, Ivo M.;Haber, Michael;Shay, David K.
通讯作者：
Shay, David K.
影响因子：
19
作者：
Kissling, E.;Valenciano, M.;Moren, A.
通讯作者：
Moren, A.
影响因子：
5.5
作者：
Jackson, Michael L.;Nelson, Jennifer C.
通讯作者：
Nelson, Jennifer C.