Multi-scale model of clogging in microfluidic devices with grid-like geometries

Multi-scale model of clogging in microfluidic devices with grid-like geometries
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网格状微流体装置堵塞的多尺度模型

DOI:
10.1098/rspa.2022.0119
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发表时间:
2022
期刊:
Physical and Engineering Sciences
影响因子:
--
通讯作者:
Fai, Thomas G.
Fai, Thomas G.
中科院分区:
--
文献类型:
--
作者:
Kelly, Gess;Fai, Thomas G.

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我们提出了一个粗粒度的理论模型来描述恒定外加流量和恒定外加压力梯度条件下微流控器件的老化过程。根据细胞的变形性对细胞进行分类的微流控设备在医疗应用方面有着巨大的前景。然而,这些微流控系统中的堵塞会导致它们的性质随着时间的推移而改变,并可能限制它们的可靠性。我们将粗粒度模型的结果与随机模拟的结果以及现有的理论研究结果进行了比较。最后,我们将该模型应用于镰刀状红细胞堵塞的实验数据,并讨论了其更广泛的适用性。
We propose a coarse-grained theoretical model to capture the ageing of microfluidic devices under different conditions including constant applied flow rate and constant applied pressure gradient. Microfluidic devices that sort cells by their deformability hold significant promise for medical applications. However, clogging in these microfluidic systems causes their properties to change over time and potentially limits their reliability. We compare the results of the coarse-grained model with those of stochastic simulations and with existing theoretical studies. Lastly, we apply the model to experimental data on the clogging of sickle red blood cells and discuss its wider applicability.
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