Lrrc34 interacts with Oct4 and has an impact on telomere length in mouse Embryonic Stem Cells.
Lrrc34 interacts with Oct4 and has an impact on telomere length in mouse Embryonic Stem Cells.
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Lrrc34 与 Oct4 相互作用并对小鼠胚胎干细胞中的端粒长度产生影响
DOI：
10.1089/scd.2021.0113
复制
发表时间：
2021
影响因子：
4
通讯作者：
中科院分区：
文献类型：
--
作者：
维持端粒长度是多能干细胞的主要特征，也是其长期未分化存活的重要前提。然而，对这些细胞中控制端粒长度和伸长的因素知之甚少。在这里，我描述了Lrrc34(富含亮氨酸的重复序列34)，它是小鼠胚胎干细胞中一个新的端粒长度调节基因。Lrrc34的下调会导致端粒酶活性和端粒长度随着时间的推移而显著减少，同时也影响已知的端粒长度相关基因的表达。在经典的山中重编程中，以Lrrc34为第五因子产生诱导的PSCs(IPSCs)提高了效率，但对所得IPSCs的端粒长度没有影响。此外，Lrrc34被发现与Oct4相互作用，连接多能性网络与端粒长度调节。
Telomere length maintenance in pluripotent stem cells (PSCs) is a main characteristic and a major premise for their undifferentiated long-term survival. However, little is known about the factors that control telomere length and elongation in these cells. Here, I describeLrrc34(leucine-rich repeat 34) as a novel telomere length regulating gene in murine embryonic stem cells. Downregulation ofLrrc34results in significant reduction of telomerase activity and telomere length over time while also influencing the expression of known telomere length-associated genes. Generating induced PSCs (iPSCs) withLrrc34as a fifth factor in classical Yamanaka reprogramming increases the efficiency but did not have an impact on telomere length in the resulting iPSCs. Moreover,Lrrc34was found to interact withOct4, connecting the pluripotency network to telomere length regulation.
DOI：
10.1073/pnas.95.15.8648
发表时间：
1998-07-21
影响因子：
11.1
作者：
Zhu, LX;Hathcock, KS;Hodes, RJ
通讯作者：
Hodes, RJ
影响因子：
3.7
作者：
Johansson H;Svensson F;Runnberg R;Simonsson T;Simonsson S
通讯作者：
Simonsson S