Pre-transplantation specification of stem cells to cardiac lineage for regeneration of cardiac tissue.
Pre-transplantation specification of stem cells to cardiac lineage for regeneration of cardiac tissue.
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DOI：
10.1007/s12015-009-9050-8
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发表时间：
2009-03
影响因子：
4.8
通讯作者：
Penn, Marc
中科院分区：
文献类型：
--
作者：
Mayorga, Maritza;Finan, Amanda;Penn, Marc
关键词：
心肌梗死（MI）是西方世界死亡率的主要原因。急性心肌梗死的治疗重点是恢复顺行血流，抑制进一步的组织损失，但不能恢复受损组织的功能。损伤心肌组织的慢性治疗涉及试图使心脏的病理性重塑最小化的药物治疗。慢性心力衰竭（CHF）的终末期治疗包括强心剂治疗，以增加存活的心肌细胞功能或机械增强心脏性能。直到心脏移植（充其量是一种有限的资源）时，治疗才集中在需要用新的收缩组织替换受伤组织的根本问题上。在这种情况下，干细胞治疗的潜力已经获得了显着的兴趣，其潜力再生或创造新的收缩性心脏组织。虽然迄今为止成人干细胞治疗在临床试验中已经表明了潜在的好处，但人们越来越不相信迄今为止使用的方法会导致心脏组织再生。由于文献已经更好地定义了参与心脏分化的途径，临床前研究表明，干细胞移植前干细胞预处理以指导干细胞分化可能是诱导心脏再生的更有效策略。在这里，我们回顾了现有的文献中移植前预处理的干细胞，试图更好地了解干细胞的行为和他们的准备，以细胞为基础的治疗心肌再生。
Myocardial infarction (MI) is a lead cause of mortality in the Western world. Treatment of acute MI is focused on restoration of antegrade flow which inhibits further tissue loss, but does not restore function to damaged tissue. Chronic therapy for injured myocardial tissue involves medical therapy that attempts to minimize pathologic remodeling of the heart. End stage therapy for chronic heart failure (CHF) involves inotropic therapy to increase surviving cardiac myocyte function or mechanical augmentation of cardiac performance. Not until the point of heart transplantation, a limited resource at best, does therapy focus on the fundamental problem of needing to replace injured tissue with new contractile tissue. In this setting, the potential for stem cell therapy has garnered significant interest for its potential to regenerate or create new contractile cardiac tissue. While to date adult stem cell therapy in clinical trials has suggested potential benefit, there is waning belief that the approaches used to date lead to regeneration of cardiac tissue. As the literature has better defined the pathways involved in cardiac differentiation, preclinical studies have suggested that stem cell pretreatment to direct stem cell differentiation prior to stem cell transplantation may be a more efficacious strategy for inducing cardiac regeneration. Here we review the available literature on pre-transplantation conditioning of stem cells in an attempt to better understand stem cell behavior and their readiness in cell-based therapy for myocardial regeneration.
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DOI：
10.1084/jem.20061916
发表时间：
2007-02-19
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Behfar A;Perez-Terzic C;Faustino RS;Arrell DK;Hodgson DM;Yamada S;Puceat M;Niederländer N;Alekseev AE;Zingman LV;Terzic A
通讯作者：
Terzic A
影响因子：
5.2
作者：
Arrell, D. Kent;Niederlaender, Nicolas J.;Terzic, Andre
通讯作者：
Terzic, Andre
影响因子：
5.2
作者：
Grauss, Robert W.;van Tuyn, John;Atsmaa, Douwe E.
通讯作者：
Atsmaa, Douwe E.
影响因子：
168.9
作者：
Askari, AT;Unzek, S;Penn, MS
通讯作者：
Penn, MS
影响因子：
10.8
作者：
Capi, Oren;Gepstein, Lior
通讯作者：
Gepstein, Lior