Reduced nucleus accumbens reactivity and adolescent depression following early-life stress.
Reduced nucleus accumbens reactivity and adolescent depression following early-life stress.
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DOI：
10.1016/j.neuroscience.2012.12.010
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发表时间：
2013-09-26
期刊：
影响因子：
3.3
通讯作者：
Tottenham N
中科院分区：
文献类型：
--
作者：
Goff B;Gee DG;Telzer EH;Humphreys KL;Gabard-Durnam L;Flannery J;Tottenham N
抑郁症是那些经历过早期生活压力（ELS）的人的常见结果。对于这些人来说，抑郁症通常在青春期增加，并似乎持续到成年，这表明与抑郁症有关的大脑系统的发育发生了变化。在发育上，与奖励学习和动机相关的边缘系统结构--目前的研究检查了ELS在38名以前被机构收容的儿童和青少年中的影响，并与一组31名没有ELS病史的青少年进行了比较。与以前的研究一致，研究结果表明，青少年的抑郁症高于有ELS病史的儿童。此外，fMRI结果显示非典型的NAcc发展，其中ELS组在青春期没有显示NAcc反应性的典型增加。因此，ELS组在青春期表现出NAcc低激活，较低的NAcc反应性与较高的抑郁评分相关。这些结果对于理解ELS如何在向青春期过渡期间通过神经发育影响抑郁症的增加具有重要意义，并强调了在儿童期识别高危个体的重要性，这是抑郁症针对性干预的潜在关键时期。
Depression is a common outcome for those having experienced early life stress (ELS). For those individuals, depression typically increases during adolescence and appears to endure into adulthood, suggesting alterations in the development of brain systems involved in depression. Developmentally, the nucleus accumbens (NAcc), a limbic structure associated with reward learning and motivation, typically undergoes dramatic functional change during adolescence; therefore, age-related changes in NAcc function may underlie increases in depression in adolescence following ELS. The current study examined the effects of ELS in 38 previously institutionalized children and adolescents in comparison to a group of 31 youth without a history of ELS. Consistent with previous research, the findings showed that depression was higher in adolescents than children with a history of ELS. Additionally, fMRI results showed atypical NAcc development, where the ELS group did not show a typical increase in NAcc reactivity during adolescence. Consequently, the ELS group showed NAcc hypoactivation during adolescence, and lower NAcc reactivity was correlated with higher depression scores. The results have important implications for understanding how ELS may influence increases in depression via neural development during the transition to adolescence and highlight the importance of identifying at-risk individuals in childhood, a potential critical period for depression-targeted intervention.
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影响因子：
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DOI：
10.1176/appi.ajp.2008.07081336
发表时间：
2009-01
期刊：
The American journal of psychiatry
影响因子：
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