Altered striatal activation predicting real-world positive affect in adolescent major depressive disorder.
Altered striatal activation predicting real-world positive affect in adolescent major depressive disorder.
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DOI：
10.1176/appi.ajp.2008.07081336
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发表时间：
2009-01
期刊：
影响因子：
--
通讯作者：
Dahl RE
中科院分区：
文献类型：
--
作者：
Forbes EE;Hariri AR;Martin SL;Silk JS;Moyles DL;Fisher PM;Brown SM;Ryan ND;Birmaher B;Axelson DA;Dahl RE
在重性抑郁症的发展过程中，奖励相关的脑功能和积极情感的现象学方面的改变越来越多地被研究。作者测试了健康和抑郁青少年中与奖励相关的大脑功能的差异，并研究了与奖励相关的大脑功能与现实世界中发生的积极情绪之间的直接联系。15名青少年重度抑郁症和28名青少年没有精神疾病史，年龄8-17岁，完成了功能磁共振成像猜测任务，涉及金钱奖励。参与者还报告了他们在自然环境中的主观积极影响，在为期4天的基于手机的生态瞬时评估。在奖励预期和奖励结果中，患有重度抑郁症的青少年比健康青少年表现出更少的纹状体反应，但背外侧和内侧前额叶皮质的反应更多。与这种抑郁症组差异相关的尾状核区激活减少与自然环境中较低的主观积极影响相关，特别是在抑郁症组中。结果支持模型的改变奖励处理和相关的积极影响，在青少年抑郁症，并表明抑郁症青少年的大脑对金钱奖励的反应与他们的情感体验在自然环境中。此外，这些结果表明，奖励处理范式捕获与现实世界的积极影响相关的大脑功能。
Alterations in reward-related brain function and phenomenological aspects of positive affect are increasingly examined in the development of major depressive disorder. The authors tested differences in reward-related brain function in healthy and depressed adolescents, and the authors examined direct links between reward-related brain function and positive mood that occurred in real-world contexts. Fifteen adolescents with major depressive disorder and 28 adolescents with no history of psychiatric disorder, ages 8–17 years, completed a functional magnetic resonance imaging guessing task involving monetary reward. Participants also reported their subjective positive affect in natural environments during a 4-day cell-phone-based ecological momentary assessment. Adolescents with major depressive disorder exhibited less striatal response than healthy comparison adolescents during reward anticipation and reward outcome, but more response in dorsolateral and medial prefrontal cortex. Diminished activation in a caudate region associated with this depression group difference was correlated with lower subjective positive affect in natural environments, particularly within the depressed group. Results support models of altered reward processing and related positive affect in young people with major depressive disorder and indicate that depressed adolescents’ brain response to monetary reward is related to their affective experience in natural environments. Additionally, these results suggest that reward-processing paradigms capture brain function relevant to real-world positive affect.
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DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Gogtay, N;Giedd, JN;Thompson, PM
通讯作者：
Thompson, PM
影响因子：
3.6
作者：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1097/00004583-199704000-00018
发表时间：
1997-04-01
影响因子：
13.3
作者：
Birmaher, B;Khetarpal, S;Neer, SM
通讯作者：
Neer, SM
DOI：
10.1073/pnas.071043098
发表时间：
2001-03-27
影响因子：
11.1
作者：
Gusnard, DA;Akbudak, E;Raichle, ME
通讯作者：
Raichle, ME