Quality of Life of Primary Aldosteronism Patients by Mineralocorticoid Receptor Antagonists.
Quality of Life of Primary Aldosteronism Patients by Mineralocorticoid Receptor Antagonists.
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DOI：
10.1210/jendso/bvab020
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发表时间：
2021-04-01
影响因子：
4.1
通讯作者：
Shibata H
中科院分区：
文献类型：
--
作者：
Yoshida Y;Yoshida R;Shibuta K;Ozeki Y;Okamoto M;Gotoh K;Masaki T;Shibata H
虽然原发性醛固酮增多症（PA）降低生活质量（QOL），但尚无关于盐皮质激素受体拮抗剂（MRA）治疗是否改善日本PA患者生活质量的报告。使用36项健康调查简表（SF-36），我们比较了PA患者治疗前后的生活质量，并评估了MRA的有效性是否因性别和血清钾水平而异。在50例诊断为PA（伴或不伴低钾血症）并接受MRA治疗的患者中，在治疗前、治疗后3个月和6个月评估SF-36评分、血压和临床特征。还对雄性和雌性进行了单独分析。健康受试者的标准平均SF-36评分为50分。所有PA患者治疗前的角色-身体（RP）（46.7 ± 1.8，P = 0.019）、一般健康（47.1 ± 1.3，P = 0.042）和角色-情感（47.2 ± 1.7，P = 0.045）SF-36子量表评分均显著低于健康受试者，但经MRA治疗后得到改善。PA女性患者的RP评分较低（45.1 ± 2.2，P = 0.008），MRA治疗未改善（46.1 ± 2.4，P = 0.036）。此外，低钾血症PA患者的心理健康SF-36子量表评分较低（43.2 ± 4.4，P = 0.041），经MRA治疗后得到改善。MRA改善了日本PA患者的生活质量，但女性PA患者可能对MRA更耐药。
Although primary aldosteronism (PA) reduces quality of life (QOL), there have been no reports on whether treatment with a mineralocorticoid receptor antagonist (MRA) improves QOL in Japanese PA patients. Using the 36-Item Short-Form Health Survey (SF-36), we compared the QOL of PA patients before and after treatment and evaluated whether the effectiveness of MRAs differs by sex and serum potassium level. In 50 patients diagnosed with PA (with or without hypokalemia) and treated with an MRA, the SF-36 scores, blood pressure, and clinical features were assessed before, and 3 and 6 months after treatment. Separate analyses were also conducted for males and females. The normative mean SF-36 score of the healthy subjects was 50. The pretreatment Role-Physical (RP) (46.7 ± 1.8, P = .019), General Health (47.1 ± 1.3, P = .042), and Role-Emotional (47.2 ± 1.7, P = .045) SF-36 subscale scores of all PA patients were significantly lower than those of healthy subjects but were improved by MRA treatment. Females with PA had a lower RP score (45.1 ± 2.2, P = .008), which was not improved by MRA treatment (46.1 ± 2.4, P = .036). In addition, PA patients with hypokalemia had a lower Mental Health SF-36 subscale score (43.2 ± 4.4, P = .041), which was improved by treatment with an MRA. MRAs improved the QOL of Japanese PA patients, but female PA patients may be more resistant to MRAs.
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影响因子：
7.2
作者：
Fukuhara, S;Bito, S;Kurokawa, K
通讯作者：
Kurokawa, K
影响因子：
3.3
作者：
Tsutsui, Hiroyuki;Ito, Hiroshi;Matsuzaki, Masunori
通讯作者：
Matsuzaki, Masunori
影响因子：
7.2
作者：
Brazier, John E.;Fukuhara, Shunichi;Kurokawa, Kiyoshi
通讯作者：
Kurokawa, Kiyoshi
影响因子：
8.3
作者：
Ito, Sadayoshi;Itoh, Hiroshi;Yamakawa, Satoru
通讯作者：
Yamakawa, Satoru
影响因子：
5.8
作者：
Funder, John W.;Carey, Robert M.;Young, William F., Jr.
通讯作者：
Young, William F., Jr.