Chromatin remodeling finds its place in the DNA double-strand break response.
Chromatin remodeling finds its place in the DNA double-strand break response.
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DOI：
10.1093/nar/gkn1071
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发表时间：
2009-04
影响因子：
14.9
通讯作者：
Richardson C
中科院分区：
文献类型：
--
作者：
Pandita TK;Richardson C
染色体双链断裂（DSB）的准确修复对于维持基因组完整性、细胞活力和预防肿瘤发生至关重要。真核细胞已经进化出有效的机制来感知和响应DSB。DNA DSB反应由分级信号网络促进，所述分级信号网络协调染色质结构变化、细胞周期检查点和多种酶活性以修复断裂的DNA末端。传感器和转换器向许多下游细胞效应器发出信号，这些效应器主要通过底物翻译后修饰发挥作用，包括磷酸化、乙酰化、甲基化和泛素化。特别是，在过去的几年中，染色质重塑和组蛋白特异性修饰的作用，以控制DNA损伤检测，信号和修复提供了重要的见解。本文综述了最近发现的影响这一复杂过程的因素和真核细胞中DNA双链断裂的修复。
The accurate repair of chromosomal double-strand breaks (DSBs) arising from exposure to exogenous agents, such as ionizing radiation (IR) and radiomimetic drugs is crucial in maintaining genomic integrity, cellular viability and the prevention of tumorigenesis. Eukaryotic cells have evolved efficient mechanisms that sense and respond to DSBs. The DNA DSB response is facilitated by hierarchical signaling networks that orchestrate chromatin structural changes, cell-cycle checkpoints and multiple enzymatic activities to repair the broken DNA ends. Sensors and transducers signal to numerous downstream cellular effectors which function primarily by substrate posttranslational modifications including phosphorylation, acetylation, methylation and ubiquitylation. In particular, the past several years have provided important insight into the role of chromatin remodeling and histones-specific modifications to control DNA damage detection, signaling and repair. This review summarizes recently identified factors that influence this complex process and the repair of DNA DSBs in eukaryotic cells.
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影响因子：
56.9
作者：
Celeste, A;Petersen, S;Nussenzweig, A
通讯作者：
Nussenzweig, A
DOI：
10.1083/jcb.200510130
发表时间：
2006-04-24
期刊：
The Journal of cell biology
影响因子：
--
作者：
Bekker-Jensen S;Lukas C;Kitagawa R;Melander F;Kastan MB;Bartek J;Lukas J
通讯作者：
Lukas J
影响因子：
16
作者：
Downs, JA;Allard, S;Côté, J
通讯作者：
Côté, J
影响因子：
14.9
作者：
Cartwright, R;Tambini, CE;Thacker, J
通讯作者：
Thacker, J
影响因子：
10.5
作者：
Bender, CF;Sikes, ML;Petrini, JHJ
通讯作者：
Petrini, JHJ