Specialized endoplasmic reticulum-derived vesicles in plants: Functional diversity, evolution, and biotechnological exploitation.
Specialized endoplasmic reticulum-derived vesicles in plants: Functional diversity, evolution, and biotechnological exploitation.
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DOI：
10.1111/jipb.13233
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发表时间：
2022-04
影响因子：
11.4
通讯作者：
中科院分区：
文献类型：
--
作者：
内质网的核心作用是分泌蛋白质的合成、折叠和质量控制。在运输到不同的亚细胞目的地之前，分泌蛋白通常在外壳蛋白复合体II(COPII)包被的囊泡中离开内质网进入高尔基体。然而，在植物中存在专门的内质网衍生小泡(ERDV)，它携带特定的蛋白质，但与COPII小泡不同，它可以作为独立的细胞器存在，或者以不依赖高尔基体的方式进入液泡。这些特殊的ERDV包括蛋白质小体和积累前体的小泡，它们在种子发育过程中在胚乳中积累储存蛋白。专门的ERDV还包括积累氨基酸序列的前体蛋白酶囊泡、KDEL尾端的半胱氨酸蛋白酶以及芥菜目植物中积累分解硫代葡萄糖苷的黑芥子酶的内质网小体。这些功能专门化的ERDV不仅可以作为存储细胞器，还可以作为信号触发的处理、激活和部署特定蛋白质的平台，在植物的生长、发育和适应反应中发挥重要作用。还开发了一些专门的ERDV来增加重组蛋白质和代谢物的产量。在这里，我们讨论我们目前对专门化ERDV的功能多样性、进化机制和生物技术应用的理解，这些与一些对植物非常重要的显著特征有关。植物产生专门的内质网(ER)衍生的小泡(ERDV)，这些小泡携带特定的ER合成的蛋白质，但不通过经典的ER到高尔基体的分泌途径。这些ERDV与重要的植物性状直接相关。本文就ERDV在植物中的功能多样性、进化和生物技术应用等方面的研究现状进行了综述。
A central role of the endoplasmic reticulum (ER) is the synthesis, folding and quality control of secretory proteins. Secretory proteins usually exit the ER to enter the Golgi apparatus in coat protein complex II (COPII)‐coated vesicles before transport to different subcellular destinations. However, in plants there are specialized ER‐derived vesicles (ERDVs) that carry specific proteins but, unlike COPII vesicles, can exist as independent organelles or travel to the vacuole in a Golgi‐independent manner. These specialized ERDVs include protein bodies and precursor‐accumulating vesicles that accumulate storage proteins in the endosperm during seed development. Specialized ERDVs also include precursor protease vesicles that accumulate amino acid sequence KDEL‐tailed cysteine proteases and ER bodies in Brassicales plants that accumulate myrosinases that hydrolyzes glucosinolates. These functionally specialized ERDVs act not only as storage organelles but also as platforms for signal‐triggered processing, activation and deployment of specific proteins with important roles in plant growth, development and adaptive responses. Some specialized ERDVs have also been exploited to increase production of recombinant proteins and metabolites. Here we discuss our current understanding of the functional diversity, evolutionary mechanisms and biotechnological application of specialized ERDVs, which are associated with some of the highly remarkable characteristics important to plants. Plants produce specialized endoplasmic reticulum (ER)‐derived vesicles (ERDVs) that carry specific ER‐synthesized proteins but do not travel through the classic ER‐to‐Golgi secretory pathway. These ERDVs are directly associated with important plant traits. This review discusses our current understanding of the functional diversity, evolution and biotechnological uses of ERDVs in plants.
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DOI：
10.1093/plcell/koab234
发表时间：
2022-01-20
期刊：
The Plant cell
影响因子：
--
作者：
Cheung AY;Cosgrove DJ;Hara-Nishimura I;Jürgens G;Lloyd C;Robinson DG;Staehelin LA;Weijers D
通讯作者：
Weijers D
DOI：
10.1073/pnas.73.9.3168
发表时间：
1976-01-01
影响因子：
11.1
作者：
CHRISPEELS, MJ;BAUMGARTNER, B;HARRIS, N
通讯作者：
HARRIS, N
影响因子：
7.8
作者：
Baumgartner, B;Tokuyasu, K T;Chrispeels, M J
通讯作者：
Chrispeels, M J
影响因子：
3.3
作者：
Granell, Susana;Baldini, Giovanna;Baldini, Giulia
通讯作者：
Baldini, Giulia
影响因子：
7.2
作者：
HARAHISHIMURA, I;TAKEUCHI, Y;NISHIMURA, M
通讯作者：
NISHIMURA, M