Nrf2 to pre-condition the brain against injury caused by products of hemolysis after ICH.
Nrf2 to pre-condition the brain against injury caused by products of hemolysis after ICH.
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DOI：
10.1007/s12975-012-0245-y
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发表时间：
2013-02
影响因子：
6.9
通讯作者：
Aronowski, Jaroslaw
中科院分区：
文献类型：
--
作者：
Zhao, Xiurong;Aronowski, Jaroslaw
Brain damage caused by intracerebral hemorrhage (ICH) is mediated in part by the toxicity of extravascular blood deposited in brain parenchyma during the hematoma formation. In this paper we discuss the therapeutic benefits and potential mechanisms associated with the activation of transcription factor Nrf2 regarding its role in defending brain tissue against toxicity of blood, a component of secondary injury. We emphasize the pleiotropic capacity of Nrf2 as it recruits multiple pathways aiming at reducing deleterious effects of blood lysis products.
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影响因子：
15.9
作者：
CID, MC;GRANT, DS;KLEINMAN, HK
通讯作者：
KLEINMAN, HK
影响因子：
4.8
作者：
Lee, JM;Shih, AY;Johnson, JA
通讯作者：
Johnson, JA
DOI：
10.1016/s1474-4422(12)70104-7
发表时间：
2012-08
期刊：
The Lancet. Neurology
影响因子：
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作者：
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通讯作者：
Xi G
影响因子：
4.4
作者：
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通讯作者：
Tannenbaum, Steven R.
影响因子：
8.3
作者：
Aronowski J;Zhao X
通讯作者：
Zhao X