Anti-Metastatic and Anti-Angiogenic Activities of Core-Shell SiO(2)@LDH Loaded with Etoposide in Non-Small Cell Lung Cancer.
Anti-Metastatic and Anti-Angiogenic Activities of Core-Shell SiO(2)@LDH Loaded with Etoposide in Non-Small Cell Lung Cancer.
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负载依托泊苷的核壳SiO2@LDH对非小细胞肺癌的抗转移和抗血管生成活性
DOI：
10.1002/advs.201600229
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发表时间：
2016-11
期刊：
影响因子：
15.1
通讯作者：
Wang, Shilong
中科院分区：
文献类型：
--
作者：
Zhu, Yanjing;Zhu, Rongrong;Wang, Mei;Wu, Bin;He, Xiaolie;Qian, Yechang;Wang, Shilong
目前，纳米颗粒在抗肿瘤研究领域受到了极大的关注。然而，迄今为止，关于核-壳SiO2@LDH（LDH：层状双氢氧化物）纳米颗粒的抗转移作用的研究仍未触及。考虑的两个新兴方面是从新的角度建立SiO2@LDH与抗癌药物结合的控制递送效果的研究。优良性能的合成SiO2 @ LDH-VP 16（VP 16：依托泊苷）被实践以显示纳米颗粒对非小细胞肺癌（NSCLC）的迁移和侵袭的抑制。体外和体内检测均表明，SiO2@LDH可以帮助VP 16更好地发挥抗转移剂的作用。另一方面，研究了抗血管生成效率、共定位以及蛋白质印迹以解释可能的机制。从共定位图像中可以观察到SiO2 @ LDH-VP 16和细胞膜/微管的清晰融合。结果提供了SiO2 @ LDH-VP 16在细胞膜和微管上发挥作用的证据。它通过减少血管形成并引发PI 3 K-AKT和FAK-Paxillin信号通路的抑制来有效抑制NSCLC的转移。SiO2 @ LDH-VP 16、整体颗粒形态以及抗转移和抗血管生成的功能可以进行调整，为癌症治疗的新策略提供新的机会。
Currently, nanoparticles have gained a great attention in the anti‐tumor research area. However, to date, studies on the anti‐metastasis action of core–shell SiO2@LDH (LDH: layered double hydroxide) nanoparticles remain untouched. Two emerging aspects considered are establishing research on the controlling delivery effect of SiO2@LDH combined with anti‐cancer medicine from a new perspective. The fine properties synthetic SiO2@LDH‐VP16 (VP16: etoposide) are practiced to exhibit the nanoparticle's suppression on migration and invasion of non‐small cell lung cancer (NSCLC). Both in vitro and in vivo inspection shows that SiO2@LDH can help VP16 better function as an anti‐metastasis agent. On the other hand, anti‐angiogenic efficiency, co‐localization, as well as western blot are investigated to explain the possible mechanism. A clear mergence of SiO2@LDH‐VP16 and cytomembrane/microtubule may be observed from co‐location images. Results offer evidence that SiO2@LDH‐VP16 plays positions on cytomembrane and microtubules. It efficiently inhibits metastasis on NSCLC by reducing vascularization, and eliciting depression of the PI3K‐AKT and FAK‐Paxillin signaling pathways. SiO2@LDH‐VP16, the overall particle morphology, and function on anti‐metastasis and anti‐angiogenic may be tuned to give new opportunities for novel strategies for cancer therapy.
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DOI：
10.1158/1078-0432.ccr-13-3227
发表时间：
2014-06-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Cook KL;Wärri A;Soto-Pantoja DR;Clarke PA;Cruz MI;Zwart A;Clarke R
通讯作者：
Clarke R
影响因子：
3.7
作者：
Attoub S;Arafat K;Gélaude A;Al Sultan MA;Bracke M;Collin P;Takahashi T;Adrian TE;De Wever O
通讯作者：
De Wever O
DOI：
10.1002/jbm.b.30648
发表时间：
2007-04-01
影响因子：
3.4
作者：
Heinrich, Laurence;Freyria, Anne-Marie;Hartmann, Daniel Jean
通讯作者：
Hartmann, Daniel Jean
影响因子：
5.8
作者：
Cortes, Javier;Baselga, Jose
通讯作者：
Baselga, Jose
影响因子：
11.2
作者：
Bröker, LE;Huisman, C;Giaccone, G
通讯作者：
Giaccone, G