Honey's Ability to Counter Bacterial Infections Arises from Both Bactericidal Compounds and QS Inhibition.
Honey's Ability to Counter Bacterial Infections Arises from Both Bactericidal Compounds and QS Inhibition.
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DOI：
10.3389/fmicb.2012.00144
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发表时间：
2012
影响因子：
5.2
通讯作者：
Rahme LG
中科院分区：
文献类型：
--
作者：
Wang R;Starkey M;Hazan R;Rahme LG
The ability of honey to kill bacterial pathogens in vitro and quickly clear even chronic or drug-resistant infections has been demonstrated by several studies. Most current research is focused on identifying the bactericidal compounds in honey, but the action of the compounds discovered is not sufficient to explain honey’s activity. By diluting honey to sub-inhibitory levels, we were able to study its impact on bacterial coordinated behavior, and discovered that honey inhibits bacterial quorum sensing (QS). Experiments to characterize and quantify honey’s effect on the QS networks of Pseudomonas aeruginosa revealed that low concentrations of honey inhibited the expression of MvfR, las, and rhl regulons, including the associated virulence factors. This research also establishes that inhibition of QS is associated with honey’s sugar content. Therefore, honey combats infections by two independent mechanisms acting in tandem: bactericidal components, which actively kill cells, and disruption of QS, which weakens bacterial coordination and virulence.
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影响因子：
6.7
作者：
Hazan R;He J;Xiao G;Dekimpe V;Apidianakis Y;Lesic B;Astrakas C;Déziel E;Lépine F;Rahme LG
通讯作者：
Rahme LG
影响因子：
56.9
作者：
AHERN, TJ;KLIBANOV, AM
通讯作者：
KLIBANOV, AM
DOI：
10.1073/pnas.251465298
发表时间：
2001-12-04
影响因子：
11.1
作者：
Cao, H;Krishnan, G;Rahme, LG
通讯作者：
Rahme, LG
DOI：
10.1073/pnas.0307694100
发表时间：
2004-02-03
影响因子：
11.1
作者：
Déziel, E;Lépine, F;Rahme, LG
通讯作者：
Rahme, LG
影响因子：
11.8
作者：
Kwakman, Paulus H. S.;Van den Akker, Johannes P. C.;Zaat, Sebastian A. J.
通讯作者：
Zaat, Sebastian A. J.