The role of secondary outcomes in multivariate meta-analysis.
The role of secondary outcomes in multivariate meta-analysis.
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DOI：
10.1111/rssc.12274
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发表时间：
2018-11
期刊：
影响因子：
--
通讯作者：
Riley RD
中科院分区：
文献类型：
--
作者：
Copas JB;Jackson D;White IR;Riley RD
单变量Meta分析涉及在多项独立研究中测量的单一关注结局。然而，许多研究也会测量次要结果。多变量Meta分析允许我们考虑这些次要结局，也可以包括主要结局缺失的研究。我们将效率E定义为多变量Meta分析的总体估计值相对于单变量Meta分析的总体估计值的方差。从n项研究的多变量Meta分析中获得的额外信息与如果主要效应的单变量Meta分析有进一步的n（1-E）/E项研究获得的额外信息相似。一项研究的次要结果的方差贡献（其强度借用）可以被认为是该研究中结果的方差矩阵与Meta分析中所有研究的方差矩阵集之间的对比。在双变量情况下，这是一个简单的图形解释，作为强度借用图。我们将讨论如何将这些发现也用于随机效应Meta分析。我们的讨论是基于对10项抗高血压临床试验的Meta分析。
Univariate meta‐analysis concerns a single outcome of interest measured across a number of independent studies. However, many research studies will have also measured secondary outcomes. Multivariate meta‐analysis allows us to take these secondary outcomes into account and can also include studies where the primary outcome is missing. We define the efficiency E as the variance of the overall estimate from a multivariate meta‐analysis relative to the variance of the overall estimate from a univariate meta‐analysis. The extra information gained from a multivariate meta‐analysis of n studies is then similar to the extra information gained if a univariate meta‐analysis of the primary effect had a further n(1−E)/E studies. The variance contribution of a study's secondary outcomes (its borrowing of strength) can be thought of as a contrast between the variance matrix of the outcomes in that study and the set of variance matrices of all the studies in the meta‐analysis. In the bivariate case this is given a simple graphical interpretation as the borrowing‐of‐strength plot. We discuss how these findings can also be used in the context of random‐effects meta‐analysis. Our discussion is motivated by a published meta‐analysis of 10 antihypertension clinical trials.
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DOI：
10.1111/j.1467-9876.2008.00650.x
发表时间：
2009-01-01
影响因子：
1.6
作者：
Copas, John;Lozada-Can, Claudia
通讯作者：
Lozada-Can, Claudia
影响因子：
2
作者：
Harbord, Roger M.;Egger, Matthias;Sterne, Jonathan A. C.
通讯作者：
Sterne, Jonathan A. C.
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
2
作者：
Ma, Yan;Mazumdar, Madhu
通讯作者：
Mazumdar, Madhu
影响因子：
2.3
作者：
Guolo, Annamaria;Varin, Cristiano
通讯作者：
Varin, Cristiano