The role of free-fatty acid receptor-4 (FFA4) in human cancers and cancer cell lines.
The role of free-fatty acid receptor-4 (FFA4) in human cancers and cancer cell lines.
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DOI：
10.1016/j.bcp.2018.02.011
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发表时间：
2018-04
影响因子：
5.8
通讯作者：
Moniri NH
中科院分区：
文献类型：
--
作者：
Senatorov IS;Moniri NH
几十年来，饮食对癌症进展的影响已经很明显，饮食脂肪酸，特别是长链单不饱和脂肪酸和多不饱和脂肪酸，已被证明在影响各种人类癌症的生长中发挥重要作用。细胞表面游离脂肪酸受体家族的发现，包括长链脂肪酸受体FFA1和FFA4，表明饮食脂肪的许多作用可能是由受体介导的。FFA4是普遍表达的，最近被证明可以调节多种重要的抗炎和代谢过程。由于FFA4目前是治疗代谢紊乱（如糖尿病和肥胖症）的一个有吸引力的药物靶点，了解其在癌症进展中的作用对药物发现过程至关重要。在这篇最新的研究中，综述了目前关于该受体在调节癌细胞增殖、迁移和侵袭以及体内肿瘤发生中的作用的知识。
A dietary influence on cancer progression has been evident for many decades, and dietary fatty acids, particularly long chain mono- and polyunsaturated fatty acids, have been shown to play significant roles in influencing growth of a variety of human cancers. The discovery of the family of cell-surface free-fatty acid receptors, which include the long-chain fatty acid receptors FFA1 and FFA4, suggest that many of the effects of dietary fats could be receptor-mediated. FFA4 is ubiquitously expressed and has recently been shown to modulate a variety of important anti-inflammatory and metabolic processes. Since FFA4 is currently an attractive drug target for treatment of metabolic disorders such as diabetes and obesity, understanding its role in cancer progression is critical towards the drug discovery process. In this research update, the current body of knowledge on the role of this receptor in regulating cancer cell proliferation, migration, and invasion, as well as in vivo tumorigenesis is reviewed.
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DOI：
10.1158/1940-6207.capr-10-0368
发表时间：
2011-08
期刊：
Cancer prevention research (Philadelphia, Pa.)
影响因子：
--
作者：
Fan YY;Ran Q;Toyokuni S;Okazaki Y;Callaway ES;Lupton JR;Chapkin RS
通讯作者：
Chapkin RS
影响因子：
4.7
作者：
Akinsete JA;Ion G;Witte TR;Hardman WE
通讯作者：
Hardman WE
DOI：
10.1016/j.bbrc.2010.05.057
发表时间：
2010-06-11
影响因子：
3.1
作者：
Burns, Rebecca N.;Moniri, Nader H.
通讯作者：
Moniri, Nader H.
影响因子：
3.6
作者：
Granci, Virginie;Cai, Fang;Pichard, Claude
通讯作者：
Pichard, Claude
DOI：
10.1016/j.bbrc.2015.08.050
发表时间：
2015-09-25
影响因子：
3.1
作者：
Fukushima, Kaori;Yamasaki, Eri;Tsujiuchi, Toshifumi
通讯作者：
Tsujiuchi, Toshifumi