Consumption of high ω-3 fatty acid diet suppressed prostate tumorigenesis in C3(1) Tag mice.
Consumption of high ω-3 fatty acid diet suppressed prostate tumorigenesis in C3(1) Tag mice.
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DOI：
10.1093/carcin/bgr238
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发表时间：
2012-01
期刊：
影响因子：
4.7
通讯作者：
Hardman WE
中科院分区：
文献类型：
--
作者：
Akinsete JA;Ion G;Witte TR;Hardman WE
前列腺癌的发病率和死亡率在西方国家很高，而西方饮食中高ω-6/ω-3多聚脂肪酸可能是一个促成因素。我们调查了成年后从接近ω-6脂肪含量的西方饮食转变为高ω-3脂肪饮食是否会降低前列腺癌的风险。将食用含玉米油的高ω-6日粮2周的雌性SV 129小鼠与纯合子C3(1)Tag转基因雄性小鼠杂交。所有雄性后代均断奶饲喂玉米油日粮（CO），直到青春期后，其中一半的雄性后代改用含有菜籽油和鱼油浓缩物（FS）的高ω-3日粮。高ω-3日粮提高了小鼠组织中ω-3脂肪含量，降低了ω-6脂肪含量。成年期高ω-3日粮小鼠（CO-FS）的前列腺和泌尿生殖系统块的平均重量显著低于终生高ω-6日粮小鼠（CO-CO）。与CO-CO小鼠相比，CO-FS小鼠前列腺背侧肿瘤发生进展较慢。与CO-CO小鼠相比，CO-FS小鼠在24周和40周时血浆睾酮水平略低，40周时雌二醇水平显著降低，40周时前列腺背侧雄激素受体（AR）表达明显减少。高ω-3日粮降低了前列腺背侧增殖和减少凋亡基因的表达。我们的研究结果表明，在C3(1)标签小鼠中，高ω-3饮食通过降低雌二醇、睾酮和AR水平，促进细胞凋亡和抑制细胞增殖来减缓前列腺肿瘤的发生。
Prostate cancer incidence and mortality are high in the Western world and high ω-6/ω-3 PUFA in the Western diet may be a contributing factor. We investigated whether changing from a diet that approximates ω-6 fat content of the Western diet to a high ω-3 fat diet at adulthood might reduce prostate cancer risk. Female SV 129 mice that had consumed a high ω-6 diet containing corn oil for 2 weeks were bred with homozygous C3(1)Tag transgenic male mice. All male offspring were weaned to the corn oil diet (CO) until postpuberty when half of the male offspring were transferred to a high ω-3 diet containing canola oil and fish oil concentrate (FS). High ω-3 diet increased ω-3 and decreased ω-6 fat content of mice tissues. Average weights of prostate and genitourinary bloc were significantly lower in mice consuming high ω-3 diet at adulthood (CO-FS) than mice fed a lifetime high ω-6 diet (CO–CO). There was slower progression of tumorigenesis in dorsalateral prostate of CO-FS than in CO–CO mice. CO-FS mice had slightly lower plasma testosterone level at 24 and 40 weeks, significantly lower estradiol level at 40 weeks and significantly less expressed androgen receptor (AR) in the dorsalateral prostate at 40 weeks than CO–CO mice. Consumption of high ω-3 diet lowered the expression of genes expected to increase proliferation and decrease apoptosis in dorsalateral prostate. Our results suggest that consumption of high ω-3 diet slows down prostate tumorigenesis by lowering estradiol, testosterone and AR levels, promoting apoptosis and suppressing cell proliferation in C3(1)Tag mice.
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影响因子：
2.8
作者：
ROSE, DP;CONNOLLY, JM
通讯作者：
CONNOLLY, JM
影响因子：
11.5
作者：
Narayanan, BA;Narayanan, NK;Reddy, BS
通讯作者：
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作者：
Hedelin, Maria;Chang, Ellen T.;Balter, Katarina Augustsson
通讯作者：
Balter, Katarina Augustsson
影响因子：
3.8
作者：
Ion G;Akinsete JA;Hardman WE
通讯作者：
Hardman WE
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168.9
作者：
Terry, P;Lichtenstein, P;Wolk, A
通讯作者：
Wolk, A