Epstein-Barr Virus (EBV)-associated gastric carcinoma.
Epstein-Barr Virus (EBV)-associated gastric carcinoma.
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DOI：
10.3390/v4123420
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发表时间：
2012-12
期刊：
影响因子：
--
通讯作者：
Yoshiyama H
中科院分区：
文献类型：
--
作者：
Iizasa H;Nanbo A;Nishikawa J;Jinushi M;Yoshiyama H
无处不在的EB病毒(EBV)与多种人类肿瘤有关，包括淋巴系和上皮性恶性肿瘤。众所周知，EBV通过激活促进B细胞淋巴瘤发生的生长和生存信号通路，持续感染健康人的记忆B细胞库。虽然在鼻咽癌和EBV相关性胃癌等上皮性肿瘤中可以观察到EBV感染细胞的单克隆性增殖，但EBV在癌变过程中的确切作用尚不完全清楚。本文就EBV相关性胃癌的特点和研究现状作一综述。EBV相关性胃癌几乎占所有胃癌病例的10%，并且表达限制性EBV潜伏基因(潜伏期I)。首先，对肺炎的定义、流行病学和临床特征进行了讨论。然后介绍了病毒基因的感染途径和致癌作用。特别有趣的是，与频繁的基因组CpG甲基化的关联和miRNA在癌症发生中的作用被专题讨论。最后，提出了针对EBV相关胃癌的治疗的可能性。
The ubiquitous Epstein-Barr virus (EBV) is associated with several human tumors, which include lymphoid and epithelial malignancies. It is known that EBV persistently infects the memory B cell pool of healthy individuals by activating growth and survival signaling pathways that can contribute to B cell lymphomagenesis. Although the monoclonal proliferation of EBV-infected cells can be observed in epithelial tumors, such as nasopharyngeal carcinoma and EBV-associated gastric carcinoma, the precise role of EBV in the carcinogenic progress is not fully understood. This review features characteristics and current understanding of EBV-associated gastric carcinoma. EBV-associated gastric carcinoma comprises almost 10% of all gastric carcinoma cases and expresses restricted EBV latent genes (Latency I). Firstly, definition, epidemiology, and clinical features are discussed. Then, the route of infection and carcinogenic role of viral genes are presented. Of particular interest, the association with frequent genomic CpG methylation and role of miRNA for carcinogenesis are topically discussed. Finally, the possibility of therapies targeting EBV-associated gastric carcinoma is proposed.
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影响因子：
5.4
作者：
Feng, WH;Hong, G;Kenney, SC
通讯作者：
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影响因子：
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作者：
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通讯作者：
Flemington, Erik K.
DOI：
10.1073/pnas.0907508106
发表时间：
2009-12-01
影响因子：
11.1
作者：
Chesnokova, Liudmila S.;Nishimura, Stephen L.;Hutt-Fletcher, Lindsey M.
通讯作者：
Hutt-Fletcher, Lindsey M.
影响因子：
5.4
作者：
Gan, YJ;Chodosh, J;Sixbey, JW
通讯作者：
Sixbey, JW