Determinants of Epstein-Barr virus-positive gastric cancer: an international pooled analysis.
Determinants of Epstein-Barr virus-positive gastric cancer: an international pooled analysis.
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DOI：
10.1038/bjc.2011.215
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发表时间：
2011-06-28
影响因子：
8.8
通讯作者：
Akiba, S.
中科院分区：
文献类型：
--
作者：
Camargo, M. C.;Murphy, G.;Koriyama, C.;Pfeiffer, R. M.;Kim, W. H.;Herrera-Goepfert, R.;Corvalan, A. H.;Carrascal, E.;Abdirad, A.;Anwar, M.;Hao, Z.;Kattoor, J.;Yoshiwara-Wakabayashi, E.;Eizuru, Y.;Rabkin, C. S.;Akiba, S.
对已发表文献的荟萃分析表明，约 9% 的胃癌含有 Epstein-Barr 病毒 (EBV)，不同性别和解剖亚位点之间存在一致且显着的差异。本研究旨在确定 EBV 阳性的其他决定因素及其联合影响。我们从对 EBV 进行一致实验室检测的 15 个国际人群中收集了 5081 例胃癌病例的个体数据，包括年龄、性别、亚位点、组织学类型、诊断分期、地理区域和诊断时期的信息。首先，我们使用随机效应荟萃分析结合了特定人群的 EBV 患病率估计。然后，我们汇总了个体水平的数据，以估计 EBV 阳性相对于所有变量的比值比，并解释了人群内的聚类。在未经调整的分析中，男性、年轻受试者、非胃窦亚位点、弥漫型组织学以及来自美洲的研究中，EBV 阳性率显着较高。多变量分析证实了与组织学和区域的显着相关性。性别与年龄（P = 0.003）和亚位点（P = 0.002）相互作用，因此两个亚位点的男性优势随着年龄的增长而下降。 EBV 阳性与阶段或时间段均无显着相关性。汇总个人层面的数据可以提供比荟萃分析更多的信息。区分组织学和地理特征以及年龄、性别和亚位点之间的相互作用进一步支持将 EBV 相关胃癌分类为独特的病因学实体。
Meta-analyses of the published literature indicate that about 9% of gastric cancers contain Epstein-Barr virus (EBV), with consistent and significant differences by sex and anatomic subsite. This study aimed to identify additional determinants of EBV positivity and their joint effects. From 15 international populations with consistent laboratory testing for EBV, we pooled individual-level data for 5081 gastric cancer cases including information on age, sex, subsite, histologic type, diagnostic stage, geographic region, and period of diagnosis. First, we combined population-specific EBV prevalence estimates using random effects meta-analysis. We then aggregated individual-level data to estimate odds ratios of EBV positivity in relation to all variables, accounting for within-population clustering. In unadjusted analyses, EBV positivity was significantly higher in males, young subjects, non-antral subsites, diffuse-type histology, and in studies from the Americas. Multivariable analyses confirmed significant associations with histology and region. Sex interacted with age (P=0.003) and subsite (P=0.002) such that male predominance decreased with age for both subsites. The positivity of EBV was not significantly associated with either stage or time period. Aggregating individual-level data provides additional information over meta-analyses. Distinguishing histologic and geographic features as well as interactions among age, sex, and subsite further support classification of EBV-associated gastric cancer as a distinct aetiologic entity.
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DOI：
10.1111/j.1349-7006.2001.tb01180.x
发表时间：
2001-09
期刊：
Japanese journal of cancer research : Gann
影响因子：
--
作者：
Koriyama C;Akiba S;Iriya K;Yamaguti T;Hamada GS;Itoh T;Eizuru Y;Aikou T;Watanabe S;Tsugane S;Tokunaga M
通讯作者：
Tokunaga M
影响因子：
2.6
作者：
Abdirad, Afshin;Ghaderi-Sohi, Siavash;Akiba, Suminori
通讯作者：
Akiba, Suminori
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
254.7
作者：
Parkin, DM;Bray, F;Pisani, P
通讯作者：
Pisani, P
影响因子：
12.7
作者：
Kattoor, J;Koriyama, C;Nair, MK
通讯作者：
Nair, MK