New and Xisting regulatory mechanisms of X chromosome inactivation.

New and Xisting regulatory mechanisms of X chromosome inactivation.
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DOI:
10.1016/j.gde.2012.02.007
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发表时间:
2012-04
影响因子:
4
通讯作者:
Lee, Jeannie T.
Lee, Jeannie T.
中科院分区:
生物学2区
文献类型:
--
作者:
Jeon, Yesu;Sarma, Kavitha;Lee, Jeannie T.

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在发育过程中,雌性哺乳动物沉默了两条X染色体中的一条,以补偿雄性中存在的一条X染色体。这一过程被称为X染色体失活(XCI),是典型的表观遗传现象,涉及非编码RNA和蛋白质因子之间的复杂相互作用。在这一领域的研究进展,从而导致了新的方法来研究表观遗传学和调控RNA的功能。在这里,我们将讨论该领域的最新进展,这些进展促进了我们对XCI及其调控机制的理解。
During development, female mammals silence one of their two X chromosomes to compensate for the presence of a single X in males. This process, termed X chromosome inactivation (XCI), is a quintessential epigenetic phenomenon and involves a complex interplay between non-coding RNAs and protein factors. Progress in this area of study has consequently resulted in new approaches to study epigenetics and regulatory RNA function. Here we will discuss recent developments in the field that have advanced our understanding of XCI and its regulatory mechanisms.
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