New and Xisting regulatory mechanisms of X chromosome inactivation.
New and Xisting regulatory mechanisms of X chromosome inactivation.
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DOI:
10.1016/j.gde.2012.02.007
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发表时间:
2012-04
影响因子:
4
通讯作者:
Lee, Jeannie T.
中科院分区:
文献类型:
--
作者:
Jeon, Yesu;Sarma, Kavitha;Lee, Jeannie T.
During development, female mammals silence one of their two X chromosomes to compensate for the presence of a single X in males. This process, termed X chromosome inactivation (XCI), is a quintessential epigenetic phenomenon and involves a complex interplay between non-coding RNAs and protein factors. Progress in this area of study has consequently resulted in new approaches to study epigenetics and regulatory RNA function. Here we will discuss recent developments in the field that have advanced our understanding of XCI and its regulatory mechanisms.
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