Are adverse childhood experiences and depression associated with impaired glucose tolerance in females? An experimental study.

Are adverse childhood experiences and depression associated with impaired glucose tolerance in females? An experimental study.
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不良的童年经历和抑郁症是否与女性糖耐量受损有关?

DOI:
10.1016/j.jpsychires.2017.07.028
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发表时间:
2017
影响因子:
4.8
通讯作者:
Christian
Christian
中科院分区:
医学2区
文献类型:
--
作者:
Wingenfeld;Linn K;Boeker;Schultebraucks;Katharina;Schulz;Stenzel;Spitzer;Carsten;Christian

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不良童年经历(ACE)会增加患精神疾病的风险,例如重度抑郁症(MDD)。越来越多的证据表明 ACE 与身体健康受损之间存在关联,例如代谢综合征。本研究的目的是评估患有和不患有 ACE 的健康个体以及患有和不患有 ACE 的抑郁症患者的几种代谢风险标志物。我们检查了 33 名患有 MDD 和 ACE 的女性、47 名患有 MDD 但没有 ACE 的女性、21 名患有 ACE 但当前或终生没有 MDD 的女性以及 36 名没有 MDD 或 ACE 的健康女性的 oGTT 中的葡萄糖和胰岛素释放。评估了甘油三酯、胆固醇、LDL、HDL、HbA1c、BMI 和腰臀比等多种代谢标志物。四组在 oGTT 中的胰岛素释放和葡萄糖浓度以及其他代谢变量方面没有差异。使用和未使用精神药物的抑郁症患者在任何结果变量上没有差异,但当前使用精神药物的患者 oGTT 中的葡萄糖浓度有较高的趋势。在这个身体健康的样本中,ACE 和 MDD 均与代谢危险因素无关。因此,代谢改变可能与 ACE 和抑郁症没有直接关系。
Adverse childhood experiences (ACE) enhance the risk for mental disorders, e.g. major depressive disorder (MDD). Increasing evidence suggests an association between ACE and impaired physical health, e.g. metabolic syndrome. The aim of this study was to assess several metabolic risk markers in healthy individuals with and without ACE and depressed patients with and without ACE.We examined glucose and insulin release in the oGTT in 33 women with MDD and ACE, 47 women with MDD without ACE, 21 women with ACE but no current or lifetime MDD and 36 healthy women without either MDD or ACE. Several metabolic markers such as triglycerides, cholesterol, LDL, HDL, HbA1c, BMI and waist to hip ratio were assessed.The four groups did neither differ in insulin release and glucose concentrations in the oGTT nor with respect to other metabolic variables. Depressed patients with and without psychotropic medication did not differ in any outcome variable, but there was a trend towards higher glucose concentrations in the oGTT in patients with current psychotropic medication.In this physically healthy sample neither ACE nor MDD were associated with metabolic risk factors. Thus, metabolic alterations might not directly be linked to ACE and depression.
性虐待、身体虐待、慢性疲劳和慢性疲劳综合症:一项基于社区的研究。
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