Long non-coding RNAs and prostate cancer.

Long non-coding RNAs and prostate cancer.
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DOI:
10.1111/cas.13352
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发表时间:
2017-11
期刊:
影响因子:
5.7
通讯作者:
Inoue S
Inoue S
中科院分区:
医学2区
文献类型:
--
作者:
Misawa A;Takayama KI;Inoue S

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长非编码RNA(Long Non-Coding RNAs,LncRNAs)是一种大于200个核苷酸的RNA转录本,不编码蛋白质,其异常表达在包括前列腺癌在内的各种类型的癌症中已被证明。前列腺癌缺乏合适的敏感和特异的生物标志物,导致过度诊断和过度治疗,使lncRNAs成为前列腺癌的新型生物标志物和治疗靶点。本文综述了前列腺癌中LncRNA表达模式和机制的研究现状,并对其在前列腺癌发生中的作用作一综述。特别是,我们专注于雄激素受体调控的lncRNAs,并在去势抵抗的前列腺癌中表达。
Long non‐coding RNAs (lncRNAs) are RNA transcripts larger than 200 nucleotides that do not code for proteins the aberrant expression of which has been documented in various types of cancer, including prostate cancer. Lack of appropriate sensitive and specific biomarkers for prostate cancer has led to overdiagnosis and overtreatment, making lncRNAs promising novel biomarkers as well as therapeutic targets for the disease. The present review attempts to summarize the current knowledge of lncRNA expression patterns and mechanisms in prostate cancer, which contribute to carcinogenesis. In particular, we focused on lncRNAs regulated by androgen receptor and expressed in castration‐resistant prostate cancer.
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