Pup exposure facilitates retrieving behavior via the oxytocin neural system in female mice
Pup exposure facilitates retrieving behavior via the oxytocin neural system in female mice
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幼仔暴露有助于雌性小鼠通过催产素神经系统恢复行为
DOI：
10.1016/j.psyneuen.2017.01.036
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发表时间：
2017
影响因子：
3.7
通讯作者：
T.
中科院分区：
文献类型：
--
作者：
Okabe;S.;Tsuneoka;Y.;Takahashi;A.;Ooyama;R.;Watarai;A.;Maeda;S.;Honda;Y.;Nagasawa;M.;Mogi;K.;Nishimori;K.;Kuroda;M.;Koide;T.;Kikusui;T.
哺乳动物的父母行为是与生俱来的，但它也受到社会经验的推动，特别是父母和婴儿之间的社会互动。与婴儿的社会互动也会导致处女动物的异地行为。催产素(OT)在调节异位行为中起着重要作用。虽然父母的行为受到内侧视前区(MPOA)和邻近区域的调节，但OT如何在这些区域作为成体-幼崽相互作用促进的异地行为的控制机制尚不清楚。本研究旨在探讨催产素通过视前区(POA)的神经活动，包括MPOA及邻近区域，促进成体-幼鼠相互作用对斜视行为的影响。为此，我们进行了行为测试，并检测了POA中OT系统的神经活动。与只接触一次幼鼠的对照组相比，多次接触幼鼠的处女小鼠在POA，特别是外侧视前区(LPO)，表现出更短的提取潜伏期和更多的c-Fos表达神经元。此外，反复暴露幼鼠后，POA内表达c-Fos的OT神经元和OTR神经元的比例增加。POA中OT的含量也显著增加。最后，在POA区注入催产素拮抗剂，可阻断反复暴露幼鼠对提取行为的促进作用。这些结果表明，反复暴露幼崽对异位行为的促进作用是通过OT系统的组织作用实现的。
Parental behavior in mammals is innate, but it is also facilitated by social experience, specifically social interactions between the parent and infant. Social interactions with infants also induce the alloparental behavior of virgin animals. Oxytocin (OT) plays an important role in mediating alloparental behavior. Although parental behavior is modulated by the medial preoptic area (MPOA) and adjacent regions, it is unclear how OT acts in these regions as a control mechanism of alloparental behavior promoted by adult-pup interaction. The aim of this study was to investigate the role of OT for facilitating effects of adult-pup interactions on alloparental behavior via neural activity of preoptic area (POA), including MPOA and adjacent area. For this purpose, we conducted behavioral tests and examined the neural activity of the OT system in POA. Virgin female mice that were repeatedly exposed to pups showed shorter retrieving latencies and higher number of c-Fos expressing neurons in POA, particular in lateral preoptic area (LPO) compared to control animals that were exposed to pups only one time. In addition, repeated pup exposure increased the proportion of OT neurons and OTR neurons expressing c-Fos in POA. The concentration of OT also significantly increased in the POA. Finally, infusion of an OT antagonist into the POA area blocked the facilitating effects of repeated pup exposure on retrieving behavior. These results demonstrated that the facilitating effects of repeated pup exposure on alloparental behavior occurred via an organizational role of the OT system.
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影响因子：
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