Regulation of convergence and extension movements during vertebrate gastrulation by the Wnt/PCP pathway.
Regulation of convergence and extension movements during vertebrate gastrulation by the Wnt/PCP pathway.
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DOI：
10.1016/j.semcdb.2009.09.004
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发表时间：
2009-10
影响因子：
7.3
通讯作者：
Solnica-Krezel L
中科院分区：
文献类型：
--
作者：
Roszko I;Sawada A;Solnica-Krezel L
脊椎动物原肠胚形成需要大量的细胞运动，以建立和塑造胚层。在原肠胚形成过程中，各个细胞的行为通过各种信号通路在时间和空间上严格协调。这些通路指导细胞增殖、形状、命运和迁移到适当的位置。脊椎动物原肠胚形成过程中的会聚和伸展（C&E）运动在胚胎体的形成中起着重要作用。在脊椎动物中，Wnt/平面细胞极性（Wnt/PCP）途径是C&E运动的关键调节剂，对于几种极化细胞行为（包括定向细胞迁移以及中间外侧和径向细胞嵌入）是必需的。然而，高度动态的间充质细胞参与C&E获得平面细胞极性的分子机制仍然没有很好的理解。胚胎中的每个细胞都需要空间和时间信息，这是其适当行为所必需的，Wnt/PCP通路通过一种尚不清楚的机制提供了这种信息。在这里，我们回顾了新的证据表明，Wnt/PCP途径在特定的细胞行为所需的C&E在斑马鱼原肠胚形成过程中，相比其他脊椎动物。我们还讨论了原肠胚运动过程中Wnt/PCP通路与其他信号通路的分子调控和相互作用的研究结果。
Vertebrate gastrulation entails massive cell movements that establish and shape the germ layers. During gastrulation, the individual cell behaviors are strictly coordinated in time and space by various signaling pathways. These pathways instruct the cells about proliferation, shape, fate and migration into proper location. Convergence and extension (C&E) movements during vertebrate gastrulation play a major role in the shaping of the embryonic body. In vertebrates, the Wnt/Planar Cell Polarity (Wnt/PCP) pathway is a key regulator of C&E movements, essential for several polarized cell behaviors, including directed cell migration, and mediolateral and radial cell intercalation. However, the molecular mechanisms underlying the acquisition of planar cell polarity by highly dynamic mesenchymal cells engaged in C&E is still not well understood. Each cell in the embryo needs spatial and temporal information, which are required for its appropriate behavior, and the Wnt/PCP pathway provides this information by a yet unclear mechanism. Here we review new evidence implicating the Wnt/PCP pathway in specific cell behaviors required for C&E during zebrafish gastrulation, in comparison to other vertebrates. We also discuss findings on the molecular regulation and the interaction of the Wnt/PCP pathway with other signaling pathways during gastrulation movements.
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