Lung cancer and vehicle exhaust in trucking industry workers.
Lung cancer and vehicle exhaust in trucking industry workers.
复制标题
卡车行业工人的肺癌和车辆排气。
DOI：
10.1289/ehp.11293
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发表时间：
2008-10
影响因子：
10.4
通讯作者：
Smith, Thomas J.
中科院分区：
文献类型：
--
作者：
Garshick, Eric;Laden, Francine;Hart, Jaime E.;Rosner, Bernard;Davis, Mary E.;Eisen, Ellen A.;Smith, Thomas J.
卡车司机患肺癌的风险升高归因于柴油废气暴露。这些研究的解释，特别是涉及柴油机废气作为一种致癌物质已受到限制，因为有限的接触测量和缺乏工作记录相关的职位名称，以确保相关的工作职责。我们建立了一个大型回顾性队列的卡车公司的工人，以评估肺癌死亡率和车辆废气暴露的措施之间的关系。研究人员获得了1985年在美国卡车运输业工会工作的31,135名男性工人的工作记录。我们使用国家死亡指数评估了2000年的肺癌死亡率，并使用工业卫生审查和当前暴露测量来确定与当前和历史使用柴油，天然气和丙烷动力车辆相关的工作。我们根据一项行业调查间接调整了吸烟因素。调整年龄和健康工人幸存者效应，肺癌危险比在与经常暴露于汽车尾气相关的工作中升高。死亡风险随着工作年限的增加而线性增加，尽管柴油卡车、城市和公路交通以及装卸码头作业的排气相关颗粒物的当前和历史模式不同，但不同工作类别的死亡风险相似。吸烟行为不能解释肺癌风险的变化。卡车运输行业的工人经常暴露于柴油和其他类型的车辆在高速公路，城市街道和装卸码头上的车辆废气，随着工作年限的增加，肺癌的风险增加。
An elevated risk of lung cancer in truck drivers has been attributed to diesel exhaust exposure. Interpretation of these studies specifically implicating diesel exhaust as a carcinogen has been limited because of limited exposure measurements and lack of work records relating job title to exposure-related job duties. We established a large retrospective cohort of trucking company workers to assess the association of lung cancer mortality and measures of vehicle exhaust exposure. Work records were obtained for 31,135 male workers employed in the unionized U.S. trucking industry in 1985. We assessed lung cancer mortality through 2000 using the National Death Index, and we used an industrial hygiene review and current exposure measurements to identify jobs associated with current and historical use of diesel-, gas-, and propane-powered vehicles. We indirectly adjusted for cigarette smoking based on an industry survey. Adjusting for age and a healthy-worker survivor effect, lung cancer hazard ratios were elevated in workers with jobs associated with regular exposure to vehicle exhaust. Mortality risk increased linearly with years of employment and was similar across job categories despite different current and historical patterns of exhaust-related particulate matter from diesel trucks, city and highway traffic, and loading dock operations. Smoking behavior did not explain variations in lung cancer risk. Trucking industry workers who have had regular exposure to vehicle exhaust from diesel and other types of vehicles on highways, city streets, and loading docks have an elevated risk of lung cancer with increasing years of work.
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影响因子：
2.1
作者：
Bunn, WB;Hesterberg, TW;Lapin, CA
通讯作者：
Lapin, CA
影响因子：
11.4
作者：
Geller, VD;Sardar, SB;Sioutas, C
通讯作者：
Sioutas, C
影响因子：
11.4
作者：
Allen, JO;Mayo, PR;Cass, GR
通讯作者：
Cass, GR
DOI：
10.1080/15287398009529933
发表时间：
1980-01-01
期刊：
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH
影响因子：
--
作者：
AXELSON, O
通讯作者：
AXELSON, O
影响因子：
8.3
作者：
Guo, H;Lee, SC;Chan, LY
通讯作者：
Chan, LY