Breast cancer characteristics and outcomes among Hispanic Black and Hispanic White women.
Breast cancer characteristics and outcomes among Hispanic Black and Hispanic White women.
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DOI：
10.1007/s10549-012-2142-1
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发表时间：
2012-08
影响因子：
3.8
通讯作者：
Li, Christopher I.
中科院分区：
文献类型：
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作者：
Banegas, Matthew P.;Li, Christopher I.
评估不同种族的西班牙裔（例如，西班牙裔黑人，西班牙裔白色）乳腺癌的结果可能会进一步解释西班牙裔女性乳腺癌负担的变化。使用SEER 17人群登记数据，我们评估了人种/种族与肿瘤分期、激素受体状态和乳腺癌特异性死亡率之间的关系。研究队列包括441，742名年龄在20-79岁之间的女性，她们在1992年1月1日至2008年12月31日期间被诊断患有原发性浸润性乳腺癌，其中包括44，246名西班牙裔白人，622名西班牙裔黑人，44，797名非西班牙裔黑人和352，077名非西班牙裔白人。与非西班牙裔白人相比，西班牙裔黑人、西班牙裔白色和非西班牙裔黑人女性出现IV期乳腺癌的风险高1.5-2.5倍。所有群体都比非西班牙裔白人更有可能被诊断为ER+/PR-（增加1.1-1.5倍）或ER-/PR-（增加1.4-2.2倍）乳腺癌。与非西班牙裔白人相比，西班牙裔黑人、西班牙裔白色和非西班牙裔黑人女性的乳腺癌特异性死亡率风险高10- 50%。我们的研究结果强调了西班牙裔和黑人女性以及不同种族的西班牙裔女性之间继续存在的乳腺癌差异。这些差异突出了可能导致西班牙裔和黑人妇女诊断为乳腺癌的结果不佳的因素，并针对这些因素制定了旨在减少乳腺癌差异的有针对性的策略。
Evaluating breast cancer outcomes specific to Hispanics of different race (e.g. Hispanic Black, Hispanic White) may further explain variations in the burden of breast cancer among Hispanic women. Using data from the SEER 17 population-based registries, we evaluated the association between race/ethnicity and tumor stage, hormone receptor status, and breast cancer-specific mortality. The study cohort of 441,742 women, aged 20–79, who were diagnosed with primary invasive breast cancer between January 1, 1992 and December 31, 2008, included 44,246 Hispanic whites, 622 Hispanic Blacks, 44,797 non-Hispanic Blacks and 352,077 non-Hispanic whites. Hispanic black, Hispanic white and non-Hispanic black women had a 1.5–2.5 fold greater risk of presenting with stage IV breast cancer compared to non-Hispanic whites. All groups were significantly more likely than non-Hispanic whites to be diagnosed with ER+/PR– (1.1–1.5 fold increase) or ER–/PR– (1.4–2.2 fold increase) breast cancer. Hispanic black, Hispanic white and non-Hispanic black women had a 10–50 % greater risk of breast cancer-specific mortality compared to non-Hispanic whites. Our findings underscore the breast cancer disparities that continue to exist for Hispanic and black women, overall, as well as between Hispanic women of different race. These disparities highlight the factors that may lead to the poor outcomes observed among Hispanic and black women diagnosed with breast cancer, and for which targeted strategies aimed at reducing breast cancer disparities could be developed.
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DOI：
10.1158/1078-0432.ccr-10-1533
发表时间：
2010-12-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
O'Brien KM;Cole SR;Tse CK;Perou CM;Carey LA;Foulkes WD;Dressler LG;Geradts J;Millikan RC
通讯作者：
Millikan RC
影响因子：
3.8
作者：
Ooi, Siew Loon;Martinez, Maria Elena;Li, Christopher I.
通讯作者：
Li, Christopher I.
影响因子：
6.2
作者：
Maly, RC;Umezawa, Y;Leake, B
通讯作者：
Leake, B
影响因子：
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作者：
Li, CI;Malone, KE;Daling, JR
通讯作者：
Daling, JR
影响因子：
6.2
作者：
Baquet, CR;Commiskey, P
通讯作者：
Commiskey, P