Disparities in breast cancer characteristics and outcomes by race/ethnicity.
Disparities in breast cancer characteristics and outcomes by race/ethnicity.
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DOI：
10.1007/s10549-010-1191-6
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发表时间：
2011-06
影响因子：
3.8
通讯作者：
Li, Christopher I.
中科院分区：
文献类型：
--
作者：
Ooi, Siew Loon;Martinez, Maria Elena;Li, Christopher I.
在美国，不同种族/族裔之间乳腺癌分期和死亡率的差异是持续存在且众所周知的。然而，很少有研究评估广泛定义为西班牙裔、亚洲裔或太平洋岛民的女性种族/族裔亚群之间的差异，特别是使用最新数据。我们利用监测、流行病学和最终结果 (SEER) 计划中 17 个基于人群的癌症登记处的数据，评估了种族/族裔与乳腺癌分期、激素受体状态、治疗和死亡率之间的关系。该队列由 2000 年 1 月至 2006 年 12 月期间被诊断患有浸润性乳腺癌的 229,594 名 40-79 岁女性组成，其中包括 176,094 名非西班牙裔白人、20,486 名黑人、15,835 名西班牙裔白人、14,951 名亚洲人、1,224 名太平洋岛民和 1,004 名美国人印第安人/阿拉斯加原住民。就统计学上显着的发现而言，美洲印第安人/阿拉斯加原住民、亚洲印第安人/巴基斯坦人、黑人、菲律宾人、夏威夷人、墨西哥人、波多黎各人和萨摩亚女性患 IV 期乳腺癌的几率是非西班牙裔白人女性的 1.3 至 7.1 倍。几乎所有群体都更有可能被诊断为雌激素受体阴性/孕激素受体阴性 (ER-/PR-) 疾病，与非西班牙裔白人相比，黑人和波多黎各女性的比值比最高（分别增加 2.4 倍和 1.9 倍）。最后，黑人、夏威夷人、波多黎各人和萨摩亚患者的乳腺癌特异性死亡率风险高出 1.5 至 1.8 倍。尽管在广泛定义为西班牙裔或亚洲裔的女性亚群体中存在很大差异，但种族/民族之间的乳腺癌差异依然存在。适合文化的、有针对性的、多管齐下的干预措施可能是减少这些差异程度的重要手段。
Disparities in breast cancer stage and mortality by race/ethnicity in the United States are persistent and well known. However, few studies have assessed differences across racial/ethnic subgroups of women broadly defined as Hispanic, Asian, or Pacific Islander, particularly using more recent data. Using data from 17 population-based cancer registries in the Surveillance, Epidemiology, and End Results (SEER) Program, we evaluated the relationships between race/ethnicity and breast cancer stage, hormone receptor status, treatment, and mortality. The cohort consisted of 229,594 women 40-79 years of age diagnosed with invasive breast carcinoma between January 2000 and December 2006, including 176,094 non-Hispanic whites, 20,486 blacks, 15,835 Hispanic whites, 14,951 Asians, 1,224 Pacific Islanders and 1,004 American Indians/Alaska Natives. With respect to statistically significant findings, American Indian/Alaska Native, Asian Indian/Pakistani, black, Filipino, Hawaiian, Mexican, Puerto Rican, and Samoan women had 1.3 to 7.1-fold higher odds of presenting with stage IV breast cancer compared to non-Hispanic white women. Almost all groups were more likely to be diagnosed with estrogen receptor-negative/progesterone receptor-negative (ER-/PR-) disease with black and Puerto Rican women having the highest odds ratios (2.4 and 1.9-fold increases, respectively) compared to non-Hispanic whites. Lastly, black, Hawaiian, Puerto Rican, and Samoan patients had 1.5 to 1.8-fold elevated risks of breast cancer specific mortality. Breast cancer disparities persist by race/ethnicity, though there is substantial variation within subgroups of women broadly defined as Hispanic or Asian. Targeted, multi-pronged interventions that are culturally appropriate may be important means of reducing the magnitudes of these disparities.
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DOI：
10.1007/s00038-004-4020-6
发表时间：
2005-01-01
期刊：
SOZIAL-UND PRAVENTIVMEDIZIN
影响因子：
--
作者：
Wampler, NS;Lash, TL;Heeren, TC
通讯作者：
Heeren, TC
影响因子：
168.9
作者：
Nattinger, AB;Hoffmann, RG;Schapira, MM
通讯作者：
Schapira, MM
影响因子：
3.3
作者：
Vainshtein, Jeffrey
通讯作者：
Vainshtein, Jeffrey
激素受体状态，肿瘤特征和预后：乳腺癌患者的前瞻性队列。
DOI：
10.1186/bcr1639
发表时间：
2007
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Dunnwald LK;Rossing MA;Li CI
通讯作者：
Li CI
影响因子：
--
作者：
Sheinfeld Gorin, Sherri;Heck, Julia E.;Smith, Suzanne J.
通讯作者：
Smith, Suzanne J.