Patient Reported Traditional Chinese Medicine Spleen Deficiency Syndrome (TCM-SDS) Scale for Colorectal Cancer: Development and Validation in China.
Patient Reported Traditional Chinese Medicine Spleen Deficiency Syndrome (TCM-SDS) Scale for Colorectal Cancer: Development and Validation in China.
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DOI：
10.1177/15347354211020105
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发表时间：
2021-01
影响因子：
2.9
通讯作者：
Yang Y
中科院分区：
文献类型：
--
作者：
Sun L;Mao JJ;Yan Y;Xu Y;Yang Y
脾虚证是结直肠癌最常见的中医证候之一。然而，到目前为止，还没有现有的患者报告结局（PRO）来评价SDS。我们的研究旨在开发和验证中国结直肠癌的PRO TCM-SDS量表。在文献回顾和专家咨询的基础上，我们开发了一个初步的8项TCM-SDS量表。然后，我们试点测试的规模（n = 40），并进行项目修订。为了进一步验证量表的信度和效度，我们对某中医院肿瘤门诊的结直肠癌患者进行了问卷调查。在最终入选并分析的100例患者中，46%为女性，中位年龄为60岁，77%患有左侧肿瘤，23%患有IV期疾病。因子负荷分析表明，TCM-SDS量表分为3个结构域。最终的TCM-SDS量表包括5个项目，包括“我感觉食欲不振”、“我感觉腹部胀满”、“我感觉四肢无力”、“我说话时感到呼吸急促”和“我的大便是无形的”（Cronbach's α系数0.76）。我们通过将5个单项相加并将其归一化为最大值10来计算量表的总分，分数越高表示脾虚证的负担越大。所有患者的平均脾虚评分为3.55 ± 1.54。其中，IV期患者的评分高于I-III期患者（4.30 vs 3.38，P = 0.015）。两周后重测信度Pearson系数为0.67，各项目之间高度相关（P < .001）。与健康对照组相比，CRC患者的脾虚评分显著较高（3.55 vs 3.23，P = 0.045）。CRC患者自报TCM-SDS量表显示了足够的初始信度和效度。该量表的建立为中医药治疗结直肠癌提供了一个有效的评价工具，为进一步研究中医药治疗结直肠癌提供了参考。
Spleen Deficiency Syndrome (SDS) is recognized as one of the most common Traditional Chinse Medicine (TCM) syndromes in patients with colorectal cancer (CRC). However so far there is no existing patient-reported outcome (PRO) to evaluate SDS. Our study aimed to develop and validate a PRO TCM-SDS scale for CRC in China. We developed an initial 8-item TCM-SDS scale for CRC based on literature review and consultation with experts. We then pilot tested the scale (n = 40) and performed item revision. We conducted a survey study among CRC patients from oncology clinics at a TCM Hospital to further determine the reliability and validity of the scale. Among 100 patients finally enrolled and analyzed in the survey study, 46% were female with median age of 60 years old, 77% had left side tumors and 23% had stage IV disease. Factor loading indicated that there were three domains within TCM-SDS scale. The final TCM-SDS scale involves 5 items including “I feel loss of appetite,” “I feel abdomen fullness,” “I feel my arms and legs lack strength,” “I feel short of breath when talking,” and “My stool is formless” (Cronbach’s alpha coefficient 0.76). We calculated the total score of the scale by summing the 5 individual items and normalizing them to a value maximum of 10, with higher scores indicating greater burden of spleen deficiency syndrome. The average spleen deficiency score for all patients was 3.55 ± 1.54. Among them, those who had stage IV disease had higher scores than stage I-III patients (4.30 vs 3.38, P = .015). Test-retest reliability after 2 weeks showed Pearson coefficient of 0.67 and all items were highly related (P < .001). Compared with healthy controls, CRC patients had significantly higher spleen deficiency scores (3.55 vs 3.23, P = .045). The patient-reported TCM-SDS scale for CRC showed adequate initial reliability and validity. The development of the scale provided an outcome measurement tool, which could facilitate future studies to better evaluate the role of TCM in treating CRC.
不同健康状况和不同年龄人群脾虚证患病率和症状特征的循证新变化：横断面观察研究
DOI：
10.1155/2014/818235
发表时间：
2014
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Zhang Y;Liu Y;Li XP;Li J;Li XF;Chen L;Jiang YY;Yu H;Shi N;Han M;Ye H;Lin ZH;Chen YZ;Liu FS;Ding X
通讯作者：
Ding X