Minus charge stimulation prevents LPS-induced liver injury by reduction of nitric oxide.
Minus charge stimulation prevents LPS-induced liver injury by reduction of nitric oxide.
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DOI：
10.3164/jcbn.2008032
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发表时间：
2008-05
影响因子：
2.4
通讯作者：
Shioda, Seiji
中科院分区：
文献类型：
--
作者：
Senga, Fujitoshi;Yin, Li;Karasuno, Hiroshi;Ohtaki, Hirokazu;Nakamachi, Tomoya;Satoh, Kazue;Shioda, Seiji
肝脏是脓毒症的主要靶器官之一，脓毒症通常伴有自由基的形成。利用负电荷预防和治疗各种根治性疾病在医学领域得到了广泛的重视。在这里，我们研究负电荷刺激（MCS）是否抑制小鼠肝脏中脂多糖（LPS）诱导的一氧化氮（NO）的产生。比较lps组与MCS组的生存率。采用电子自旋共振技术测定肝脏NO自由基水平。肝损伤时测定血清丙氨酸转氨酶（ALT）。MCS显著提高lps处理小鼠的存活率，抑制血清ALT水平升高。MCS还能显著降低lps处理小鼠肝组织中NO自由基的产生。综上所述，我们的研究结果表明，MCS可能通过抑制肝脏NO自由基的产生来预防lps诱导的肝损伤。
The liver is one of the major target organs affected in sepsis that are usually accompanied with free radical formation. The use of minus charge for the prevention and cure of various radical related diseases is gaining wide importance in the medicinal field. Here, we investigate whether minus charge stimulation (MCS) inhibits nitric oxide (NO) production induced by lipopolysaccharide (LPS) in the mice liver. The survival rate was compared in LPS-treated group with MCS group. The liver NO radical was measured using electron spin resonance technique. Serum alanine transaminase (ALT) was estimated for liver injury. MCS significantly improved the survival rate of LPS-treated mice and inhibited increase of ALT in serum levels. MCS also reduced NO radical production significantly in the LPS-treated mice liver tissue. In conclusion, our results indicate that MCS prevents LPS-induced liver injury, which may be through the inhibition of liver NO radical production.
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DOI：
10.1073/pnas.0510352103
发表时间：
2006-03-21
影响因子：
11.1
作者：
Nakai, K;Kadiiska, MB;Mason, RP
通讯作者：
Mason, RP
DOI：
10.1111/j.1749-6632.2002.tb04074.x
发表时间：
2002-01-01
期刊：
NITRIC OXIDE: NOVEL ACTIONS, DELETERIOUS EFFECTS AND CLINICAL POTENTIAL
影响因子：
--
作者：
Hon, WM;Lee, KH;Khoo, HE
通讯作者：
Khoo, HE
DOI：
10.1016/0006-291x(87)90491-8
发表时间：
1987-12-31
影响因子：
3.1
作者：
KYLE, ME;MICCADEI, S;FARBER, JL
通讯作者：
FARBER, JL
DOI：
10.1006/bbrc.1997.6622
发表时间：
1997-05-08
影响因子：
3.1
作者：
Shirahata, S;Kabayama, S;Katakura, Y
通讯作者：
Katakura, Y
DOI：
10.1152/ajpgi.1995.269.2.g297
发表时间：
1995-08-01
影响因子：
4.5
作者：
WANG, JH;REDMOND, HP;BOUCHIERHAYES, D
通讯作者：
BOUCHIERHAYES, D