Non-steroid anti-inflammatory drugs, prostaglandins, and cancer.
Non-steroid anti-inflammatory drugs, prostaglandins, and cancer.
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DOI：
10.1186/2045-3701-3-8
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发表时间：
2013-02-06
影响因子：
7.5
通讯作者：
Nie D
中科院分区：
文献类型：
--
作者：
Allaj V;Guo C;Nie D
脂肪酸参与多种途径，在健康中起着关键作用。花生四烯酸衍生的二十烷基类化合物在癌症研究领域受到了广泛的关注。花生四烯酸从磷脂膜释放后，可通过环氧合酶、脂氧合酶或P450环氧合酶途径代谢成不同类别的二十烷类化合物。非类固醇抗炎药(NSAIDs)被广泛用作缓解轻微疼痛的止痛药、退烧药和消炎药。大多数非甾体抗炎药都是环氧合酶的非选择性抑制剂，环氧合酶是前列腺素形成的限速酶。在许多癌症中，长期使用一些非类固醇抗炎药与降低发病率和死亡率有关。在这篇综述中，我们从癌症生物学的角度对前列腺素及其同源受体的生物活性进行了评价。现有文献支持这些脂质介质在很大程度上参与了癌症的发生和发展。
Fatty acids are involved in multiple pathways and play a pivotal role in health. Eicosanoids, derived from arachidonic acid, have received extensive attention in the field of cancer research. Following release from the phospholipid membrane, arachidonic acid can be metabolized into different classes of eicosanoids through cyclooxygenases, lipoxygenases, or p450 epoxygenase pathways. Non-steroid anti-inflammatory drugs (NSAIDs) are widely consumed as analgesics to relieve minor aches and pains, as antipyretics to reduce fever, and as anti-inflammatory medications. Most NSAIDs are nonselective inhibitors of cyclooxygenases, the rate limiting enzymes in the formation of prostaglandins. Long term use of some NSAIDs has been linked with reduced incidence and mortality in many cancers. In this review, we appraise the biological activities of prostanoids and their cognate receptors in the context of cancer biology. The existing literature supports that these lipid mediators are involved to a great extent in the occurrence and progression of cancer.
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DOI：
10.1006/bbrc.1993.2470
发表时间：
1993-11-30
影响因子：
3.1
作者：
AN, SZ;YANG, JH;GOETZL, EJ
通讯作者：
GOETZL, EJ
影响因子：
4.4
作者：
Chen, Yingying;Perussia, Bice;Campbell, Kerry S.
通讯作者：
Campbell, Kerry S.
影响因子：
20.1
作者：
Cogolludo, A;Moreno, L;Perez-Vizcaino, F
通讯作者：
Perez-Vizcaino, F
影响因子：
4.8
作者：
Chan, BS;Satriano, JA;Schuster, VL
通讯作者：
Schuster, VL
四种大鼠前列腺素 E2 前列腺素受体亚型的分子克隆和表征
影响因子：
5
作者：
Boie, Y;Stocco, R;Abramovitz, M
通讯作者：
Abramovitz, M