Maternal overnutrition is associated with altered synaptic input to lateral hypothalamic area.
Maternal overnutrition is associated with altered synaptic input to lateral hypothalamic area.
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DOI：
10.1016/j.molmet.2023.101702
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发表时间：
2023-05
影响因子：
8.1
通讯作者：
Rossi, Mark A.
中科院分区：
文献类型：
--
作者：
Shrivastava, Kuldeep;Swaminathan, Thaarini;Barlotta, Alessandro;Athreya, Vikshar;Choudhry, Hassan;Rossi, Mark A.
关键词：
母亲营养过剩与后代的不良后果有关，包括肥胖和糖尿病风险增加。在这里，我们的目的是测试母亲肥胖对外侧下丘脑喂养回路功能的影响，并确定与体重调节的关系。利用母体肥胖的小鼠模型，我们评估了围产期营养过剩如何影响成年后代的食物摄入和体重调节。然后，我们使用通道视紫红质辅助电路映射和电生理记录，以评估在一个扩展的杏仁核外侧下丘脑通路的突触连接。我们表明，母亲在怀孕期间和整个哺乳期营养过剩产生的后代比对照组断奶前更重。当断奶后进食时，营养过度的后代的体重恢复到对照水平。然而，当成年后出现非常可口的食物时，男性和女性母亲过度营养的后代都非常容易患上饮食诱导的肥胖症。这与杏仁核外侧下丘脑通路的突触强度改变有关，这是由发育生长率预测的。此外，从终纹床核接收突触输入的外侧下丘脑神经元在母体营养过剩后具有增强的兴奋性输入，这是由早期生命生长率预测的。总之，这些结果表明，母亲肥胖重新布线下丘脑喂养电路，使后代易患代谢功能障碍的一种方式。母亲营养过剩会产生贪食和肥胖倾向的后代。母体营养过剩增加BNST→LHA通路中的兴奋性输入早期生命生长率预测BNST→LHA通路中的突触强度
Maternal overnutrition is associated with adverse outcomes in offspring, including increased risk for obesity and diabetes. Here, we aim to test the effects of maternal obesity on lateral hypothalamic feeding circuit function and determine the relationship with body weight regulation. Using a mouse model of maternal obesity, we assessed how perinatal overnutrition affected food intake and body weight regulation in adult offspring. We then used channelrhodopsin-assisted circuit mapping and electrophysiological recordings to assess the synaptic connectivity within an extended amygdala-lateral hypothalamic pathway. We show that maternal overnutrition during gestation and throughout lactation produces offspring that are heavier than controls prior to weaning. When weaned onto chow, the body weights of over-nourished offspring normalize to control levels. However, when presented with highly palatable food as adults, both male and female maternally over-nourished offspring are highly susceptible to diet-induced obesity. This is associated with altered synaptic strength in an extended amygdala-lateral hypothalamic pathway, which is predicted by developmental growth rate. Additionally, lateral hypothalamic neurons receiving synaptic input from the bed nucleus of the stria terminalis have enhanced excitatory input following maternal overnutrition which is predicted by early life growth rate. Together, these results demonstrate one way in which maternal obesity rewires hypothalamic feeding circuits to predispose offspring to metabolic dysfunction. Maternal overnutrition yields hyperphagic and obesity-prone offspring. Maternal overnutrition increases excitatory input in the BNST→LHA pathway Early life growth rate predicts synaptic strength in the BNST→LHA pathway
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影响因子：
4.8
作者：
Dearden L;Balthasar N
通讯作者：
Balthasar N
母体饮食以性别特定方式破坏胎盘脑轴。
影响因子：
20.8
作者：
Ceasrine, Alexis M.;Devlin, Benjamin A.;Bolton, Jessica L.;Green, Lauren A.;Jo, Young Chan;Huynh, Carolyn;Patrick, Bailey;Washington, Kamryn;Sanchez, Cristina L.;Joo, Faith;Campos-Salazar, A. Brayan;Lockshin, Elana R.;Kuhn, Cynthia;Murphy, Susan K.;Simmons, Leigh Ann;Bilbo, Staci D.
通讯作者：
Bilbo, Staci D.
影响因子：
4.8
作者：
Chen, Hui;Simar, David;Morris, Margaret J.
通讯作者：
Morris, Margaret J.
DOI：
10.1152/ajpendo.00559.2009
发表时间：
2010-03-01
影响因子：
5.1
作者：
Hall, Kevin D.
通讯作者：
Hall, Kevin D.
影响因子：
25
作者：
Giardino WJ;Eban-Rothschild A;Christoffel DJ;Li SB;Malenka RC;de Lecea L
通讯作者：
de Lecea L