Water-fat MRI for assessing changes in bone marrow composition due to radiation and chemotherapy in gynecologic cancer patients.
Water-fat MRI for assessing changes in bone marrow composition due to radiation and chemotherapy in gynecologic cancer patients.
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DOI：
10.1002/jmri.24071
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发表时间：
2013-12
影响因子：
4.4
通讯作者：
Hui, Susanta
中科院分区：
文献类型：
--
作者：
Bolan, Patrick J.;Arentsen, Luke;Sueblinvong, Thanasak;Zhang, Yan;Moeller, Steen;Carter, Jori S.;Downs, Levi S., Jr.;Ghebre, Rahel;Yee, Douglas;Froelich, Jerry;Hui, Susanta
评估使用脂肪分数成像测量接受癌症治疗的患者大区域骨髓成分变化的可行性。本研究招募了 13 名患有妇科恶性肿瘤并接受放疗和/或化疗的女性。受试者在基线（手术后但放疗或化疗前）、治疗后 6 个月和 12 个月时通过 3T MR 扫描仪进行成像。水脂肪成像用于生成从股骨中部延伸到 L3 的高分辨率 3D 信号脂肪分数 (sFF) 图。通过测量 L4 椎骨、股骨颈和对照组织的骨髓 sFF 来评估治疗变化。对 9 名女性的治疗前和 6 个月扫描进行了比较。 L4 椎体骨髓 (p=0.04) 和股骨颈 (p=0.03) 的 sFF 均显着增加，而对照区域未观察到显着变化。定性地讲，化疗的变化在空间上更加均匀，而放射引起的变化在目标放射野内部和附近的骨髓区域最大。水-脂肪磁共振成像对红/黄骨髓成分的变化敏感，可用于对治疗引起的骨髓损伤进行定量和定性评估。
To assess the feasibility of using fat-fraction imaging for measuring marrow composition changes over large regions in patients undergoing cancer therapy. Thirteen women with gynecologic malignancies who were to receive radiation and/or chemotherapy were recruited for this study. Subjects were imaged on a 3T MR scanner at baseline (after surgery but before radiation or chemotherapy), 6 months, and 12 months after treatment. Water-fat imaging was used to generate high-resolution, 3D signal fat fraction (sFF) maps extending from mid-femur to L3. Treatment changes were assessed by measuring marrow sFF in the L4 vertebra, femoral necks, and control tissues. Pre-treatment and 6-month scans were compared in nine women. sFF increased significantly in both the L4 vertebral marrow (p=0.04) and the femoral necks (p=0.03), while no significant change was observed in control regions. Qualitatively, chemotherapy changes were more uniform in space, whereas the radiation-induced changes were largest in marrow regions inside and close to the target radiation field. Water-Fat MR imaging is sensitive to changes in red/yellow marrow composition, and can be used for quantitative and qualitative assessment of treatment-induced marrow damage.
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DOI：
10.1038/oby.2010.106
发表时间：
2011-01
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
Bredella MA;Torriani M;Ghomi RH;Thomas BJ;Brick DJ;Gerweck AV;Rosen CJ;Klibanski A;Miller KK
通讯作者：
Miller KK
影响因子：
5
作者：
Gold, GE;Han, E;Beaulieu, C
通讯作者：
Beaulieu, C
影响因子：
3.3
作者：
Blaimer, Martin;Breuer, Felix A.;Jakob, Peter M.
通讯作者：
Jakob, Peter M.
影响因子：
56.9
作者：
Hong, JH;Hwang, ES;Yaffe, MB
通讯作者：
Yaffe, MB
影响因子：
3.3
作者：
Reeder, SB;Pineda, AR;Pelc, NJ
通讯作者：
Pelc, NJ