Vertebral bone marrow fat is positively associated with visceral fat and inversely associated with IGF-1 in obese women.
Vertebral bone marrow fat is positively associated with visceral fat and inversely associated with IGF-1 in obese women.
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DOI：
10.1038/oby.2010.106
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发表时间：
2011-01
期刊：
影响因子：
--
通讯作者：
Miller KK
中科院分区：
文献类型：
--
作者：
Bredella MA;Torriani M;Ghomi RH;Thomas BJ;Brick DJ;Gerweck AV;Rosen CJ;Klibanski A;Miller KK
最近的研究表明，骨骼和脂肪之间存在着重要的生理联系。骨细胞和脂肪细胞起源于骨髓内同一间充质前体细胞，能够分化为脂肪细胞或成骨细胞。体重指数的增加似乎可以预防骨质疏松症。然而，最近的研究表明内脏脂肪对骨骼健康有不利影响。内脏脂肪的增加也可能与生长激素（GH）和胰岛素样生长因子1 （IGF-1）水平的降低有关，而生长激素和胰岛素样生长因子1对维持骨骼稳态很重要。本研究的目的是评估绝经前肥胖妇女椎体骨髓脂肪与骨小梁骨密度（BMD）、腹部脂肪库、生长激素和IGF-1之间的关系。我们研究了47名不同BMI（范围：18-41 kg/m2，平均30±7 kg/m2）的绝经前妇女，她们用质子磁共振波谱（1H-MRS）测量椎体骨髓脂肪，用计算机断层扫描（CT）测量身体成分和小梁骨密度，以及GH和IGF-1水平。高内脏脂肪的女性骨髓脂肪高于低内脏脂肪的女性。骨髓脂肪与内脏脂肪呈正相关，与骨密度无关。椎体骨髓脂肪与骨小梁骨密度呈负相关。椎体骨髓脂肪也与IGF-1呈负相关，与内脏脂肪无关。我们的研究表明，椎体骨髓脂肪与内脏脂肪呈正相关，与IGF-1和BMD呈负相关。这表明内脏脂肪对骨骼健康的有害影响可能部分是由IGF-1介导的，IGF-1是脂肪和骨骼谱系的重要调节因子。
Recent studies have demonstrated an important physiologic link between bone and fat. Bone and fat cells arise from the same mesenchymal precursor cell within bone marrow, capable of differentiation into adipocytes or osteoblasts. Increased BMI appears to protect against osteoporosis. However, recent studies have suggested detrimental effects of visceral fat on bone health. Increased visceral fat may also be associated with decreased growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels which are important for maintenance of bone homeostasis. The purpose of our study was to assess the relationship between vertebral bone marrow fat and trabecular bone mineral density (BMD), abdominal fat depots, GH and IGF-1 in premenopausal women with obesity. We studied 47 premenopausal women of various BMI (range: 18–41 kg/m2, mean 30 ± 7 kg/m2) who underwent vertebral bone marrow fat measurement with proton magnetic resonance spectroscopy (1H-MRS), body composition, and trabecular BMD measurement with computed tomography (CT), and GH and IGF-1 levels. Women with high visceral fat had higher bone marrow fat than women with low visceral fat. There was a positive correlation between bone marrow fat and visceral fat, independent of BMD. There was an inverse association between vertebral bone marrow fat and trabecular BMD. Vertebral bone marrow fat was also inversely associated with IGF-1, independent of visceral fat. Our study showed that vertebral bone marrow fat is positively associated with visceral fat and inversely associated with IGF-1 and BMD. This suggests that the detrimental effect of visceral fat on bone health may be mediated in part by IGF-1 as an important regulator of the fat and bone lineage.
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影响因子：
7.1
作者：
BORKAN, GA;GERZOF, SG;SILBERT, JE
通讯作者：
SILBERT, JE
影响因子：
4.9
作者：
Papakitsou, EF;Margioris, AN;Stergiopoulos, K
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Stergiopoulos, K
影响因子：
5.8
作者：
Bredella, Miriam A.;Fazeli, Pouneh K.;Klibanski, Anne
通讯作者：
Klibanski, Anne
影响因子：
5.8
作者：
Biller, BMK;Samuels, MH;Hartman, ML
通讯作者：
Hartman, ML
影响因子：
5.8
作者：
Makimura, Hideo;Stanley, Takara;Grinspoon, Steven
通讯作者：
Grinspoon, Steven