Coupled Computational Analysis of Arterial LDL Transport -- Effects of Hypertension
Coupled Computational Analysis of Arterial LDL Transport -- Effects of Hypertension
复制标题
动脉低密度脂蛋白转运的耦合计算分析——高血压的影响
DOI：
10.1080/10255840290010733
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发表时间：
2002
影响因子：
1.6
通讯作者：
C. R. Ethier
中科院分区：
文献类型：
--
作者：
D. K. Stangeby;C. R. Ethier
高血压是动脉粥样硬化的危险因素，它会增加动脉壁对低密度脂蛋白 (LDL) 的摄取。我们这项工作的目标是使用计算模型来识别可能部分导致这种影响的物理因素。以耦合方式计算动脉模型管腔和壁中的流体流动和质量传递模式，尽可能地重复先前的实验研究，其中在直的切除动脉段中测量动脉壁中 LDL 的摄取。在有血流和无血流的情况下，模拟预测当动脉压从 120 毫米汞柱增加到 160 毫米汞柱时，动脉壁处 LDL 的浓差极化会增加。然而，这仅导致动脉壁内平均 LDL 浓度略有增加。然而，如果允许内皮对 LDL 的渗透性随动脉内压变化，则模拟预测在较高压力下 LDL 的摄取将增强 1.9-2.6 倍。这种增加的幅度与实验数据一致。我们的结论是，动脉内压升高所增强的浓差极化效应无法解释高血压条件下 LDL 摄取的增加。相反，这些数据与压力相关的内皮对 LDL 通透性的增加最为一致。
Hypertension, a risk factor for atherosclerosis, increases the uptake of low density lipoproteins (LDL) by the arterial wall. Our objective in this work was to use computational modeling to identify physical factors that could be partially responsible for this effect. Fluid flow and mass transfer patterns in the lumen and wall of an arterial model were computed in a coupled manner, replicating as closely as possible previous experimental studies in which LDL uptake into the artery wall was measured in straight, excised arterial segments. Under conditions of both flow and no-flow, simulations predicted an increase in concentration polarization of LDL at the artery wall when arterial pressure was increased from 120 to 160 mmHg. However, this led to only a slight increase in mean LDL concentration within the arterial wall. However, if the permeability of the endothelium to LDL was allowed to vary with intra-arterial pressure, then the simulations predicted that the uptake of LDL would be enhanced 1.9-2.6 fold at higher pressure. The magnitude of this increase was consistent with experimental data. We conclude that the concentration polarization effects, enhanced by elevated intra-arterial pressure, cannot explain the increase in LDL uptake seen under hypertensive conditions. Instead, the data are most consistent with a pressure-linked increase in endothelial permeability to LDL.
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DOI：
10.1115/1.2891384
发表时间：
1992-08-01
影响因子：
1.7
作者：
NEREM, RM
通讯作者：
NEREM, RM
质量运输、动脉粥样硬化形成和风险。
DOI：
10.1161/01.atv.7.1.88
发表时间：
1987
期刊：
Arteriosclerosis (Dallas, Tex.)
影响因子：
--
作者：
Fry,DL
通讯作者：
Fry,DL
内皮和内弹力层在调节体内大分子进入动脉中的相对意义。
影响因子：
20.1
作者：
Penn,MS;Saidel,GM;Chisolm,GM
通讯作者：
Chisolm,GM
血流动力学改变动脉低密度脂蛋白代谢。
影响因子：
4.3
作者：
Warty,VS;Calvo,WJ;Berceli,SA;Pham,SM;Durham,SJ;Tanksale,SK;Klein,EC;Herman,IM;Borovetz,HS
通讯作者：
Borovetz,HS
影响因子：
4.6
作者：
S. Glagov;C. Zarins;D. Giddens;D. Ku
通讯作者：
S. Glagov;C. Zarins;D. Giddens;D. Ku