Inhomogeneous sodium accumulation in the ischemic core in rat focal cerebral ischemia by 23Na MRI.
Inhomogeneous sodium accumulation in the ischemic core in rat focal cerebral ischemia by 23Na MRI.
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DOI：
10.1002/jmri.21816
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发表时间：
2009-07
影响因子：
4.4
通讯作者：
Jones, Stephen C.
中科院分区：
文献类型：
--
作者：
Yushmanov, Victor E.;Kharlamov, Alexander;Yanovski, Boris;LaVerde, George;Boada, Fernando E.;Jones, Stephen C.
To test the hypotheses that 1) the regional heterogeneity of brain sodium concentration ([Na+]br) provides a parameter for ischemic progression not available from apparent diffusion coefficient (ADC) data, and 2) [Na+]br increases more in ischemic cortex than in the caudate putamen (CP) with its lesser collateral circulation after middle cerebral artery occlusion in the rat. Twisted projection imaging 23Na MRI was performed at 3 T. [Na+]br was independently determined by flame photometry. The ischemic core was localized by ADC, by microtubule-associated protein-2 immunohistochemistry, and by changes in surface reflectivity. Within the ischemic core, the ADC ratio relative to the contralateral tissue was homogeneous (0.63 ± 0.07), whereas the rate of [Na+]br increase (slope) was heterogeneous (P < 0.005): 22 ± 4%/h in the sites of maximum slope vs. 14 ± 1%/h elsewhere (here 100% is [Na+]br in the contralateral brain). Maximum slopes in the cortex were higher than in CP (P < 0.05). In the ischemic regions, there was no slope/ADC correlation between animals and within the same brain (P > 0.1). Maximum slope was located at the periphery of ischemic core in 8/10 animals. Unlike ADC, 23Na MRI detected within-core ischemic lesion heterogeneity.
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