Measurement of infarct size in acute canine myocardial infarction by single-photon emission computed tomography with technetium-99m pyrophosphate.
Measurement of infarct size in acute canine myocardial infarction by single-photon emission computed tomography with technetium-99m pyrophosphate.
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使用 99m 焦磷酸锝进行单光子发射计算机断层扫描测量急性犬心肌梗塞的梗塞面积。
DOI：
10.1016/0002-9149(84)90328-x
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Willerson,JT
中科院分区：
文献类型：
--
作者：
Lewis,SE;DevousSr,MD;Corbett,JR;Izquierdo,C;Nicod,P;Wolfe,CL;Parkey,RW;Buja,LM;Willerson,JT
心肌梗死（MI）的部位和范围是患者病程的重要预测因素。本研究测试了以下假设：可以使用旋转伽马相机单光子发射计算机断层扫描（SPECT）和锝-99m焦磷酸盐（PPI）准确测量MI尺寸，并且这些测量的准确性与MI位置和透壁或非透壁分布无关。38只犬结扎冠状动脉左前降支（14只）或左回旋支（24只）中段以下48小时后行SPECT检查。对投影图像的旋转中心和视野不均匀性进行校正，并用一维低通滤波器处理以减少肋骨活动。包括整个左心室在内的16个0.5 cm厚的横截面通过滤波反投影、低通滤波、对比增强和三维边界增强算子处理进行重建。使用结合方向导数和阈值的算法自动标记每个切片中PPi摄取的边界，并要求边界在3维中的连续性。将显示异常示踪剂摄取的体积元素总数相加，校正为绝对体积，并乘以心肌的比重。将闪烁照相Ml重量与病理Ml重量进行比较，闪烁照相Ml重量与病理Ml重量之间具有良好的相关性。与透壁性Ml相比，非透壁性Ml的相关性较差，这很可能是尺寸的单独函数，因为重量小于10 g（n = 12，范围1.3 - 9.5 g）的Ml，透壁性和非透壁性均显示出相似的相关性：S = 1.07 × P + 0.56（r = 0.81，斜率的标准误= 0.245）。因此，SPECT与PPi可以提供准确的测量实验犬MI大小的MI位置和心内膜到心外膜的程度无关。
The location and extent of myocardial infarction (MI) are important predictors of patient course. The current study tests the hypothesis that Ml size could be measured accurately using rotating gamma camera single-photon emission computed tomography (SPECT) and technetium-99m pyrophosphate (PPI) and that the accuracy of these measurements was independent of Ml location and transmural or nontransmural distribution. SPECT was performed in 38 dogs 48 hours after ligation of the left anterior descending coronary artery (14 dogs) or left circumflex coronary artery (LC) (24 dogs) at the mid-level or below. Projection images were corrected for center-of-rotation and field nonuniformity and processed with a 1-dimensional low-pass filter to diminish rib activity. Sixteen 0.5-cm-thick transverse sections, including the entire left ventricle, were reconstructed by filtered backprojection, low-pass filtered, contrast enhanced and processed with a 3-dimensional boundary enhancement operator. The boundary of PPi uptake in each slice was marked automatically using an algorithm that combined a directional derivative and a threshold, and required continuity of the boundary in 3 dimensions. The total number of volume elements that showed abnormal tracer uptake were summed, corrected to absolute volume, and multiplied by the specific weight of cardiac muscle. Scintigraphic Ml weight was compared with pathologic Ml weight.There was an excellent correlation between scintigraphic and pathologic Ml weight. The poorer correlation for nontransmural compared with transmural Mls is most likely a function of size alone, since Mls that weighed less than 10 g (n = 12, range 1.3 to 9.5 g), both transmural and nontransmural, showed a similar correlation: S = 1.07 × P + 0.56 (r = 0.81, standard error of the slope = 0.245). Thus, SPECT with PPi can provide accurate measurements of experimental canine MI size independent of MI location and endocardial-to-epicardial extent.
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DOI：
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DOI：
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