Cutting edge: FYCO1 recruitment to dectin-1 phagosomes is accelerated by light chain 3 protein and regulates phagosome maturation and reactive oxygen production.
Cutting edge: FYCO1 recruitment to dectin-1 phagosomes is accelerated by light chain 3 protein and regulates phagosome maturation and reactive oxygen production.
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DOI：
10.4049/jimmunol.1302835
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发表时间：
2014-02-15
期刊：
影响因子：
--
通讯作者：
Underhill DM
中科院分区：
文献类型：
--
作者：
Ma J;Becker C;Reyes C;Underhill DM
LC3 相关的吞噬作用是一个过程，其中 LC3（一种典型地参与吞噬细胞内物质（自噬）的蛋白质）在细胞外有效负载的内化过程中被募集到传统的吞噬体中。 LC3 与吞噬体的关联与调节微生物杀灭、抗原加工和吞噬体成熟有关，但 LC3 影响这些过程的机制尚不清楚。在这项研究中，我们报道了 FYCO1（一种先前参与自噬体运输的蛋白质）被 LC3 直接招募到 Dectin-1 吞噬体。在 LC3 相关的吞噬过程中，FYCO1 募集促进早期 p40phox 阳性吞噬体成熟为晚期 LAMP1 阳性吞噬体。当 FYCO1 缺乏时，吞噬体保持 p40phox 阳性的时间更长，并产生更多的活性氧。
LC3-associated phagocytosis is a process in which LC3, a protein canonically involved in engulfing intracellular materials (autophagy), is recruited to traditional phagosomes during internalization of extracellular payloads. LC3 association with phagosomes has been implicated in regulating microbial killing, antigen processing, and phagosome maturation, however the mechanism by which LC3 influences these processes has not been clear. In this study, we report that FYCO1, a protein previously implicated in autophagosome trafficking, is recruited directly by LC3 to Dectin-1 phagosomes. During LC3-associated phagocytosis, FYCO1 recruitment facilitates maturation of early p40phox-positive phagosomes into late LAMP1-positive phagosomes. When FYCO1 is lacking, phagosomes stay p40phox-positive longer and produce more reactive oxygen.
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影响因子：
64.5
作者：
Kumar, Dhiraj;Nath, Lekha;Rao, Kanury V. S.
通讯作者：
Rao, Kanury V. S.
影响因子：
20.3
作者：
Underhill, DM;Rossnagle, E;Simmons, RM
通讯作者：
Simmons, RM
影响因子：
56.9
作者：
Nakagawa, I;Amano, A;Yoshimori, T
通讯作者：
Yoshimori, T
影响因子：
8.8
作者：
Aldahmesh, Mohammed A.;Khan, Arif O.;Alkuraya, Fowzan S.
通讯作者：
Alkuraya, Fowzan S.
DOI：
10.4049/jimmunol.182.2.1146
发表时间：
2009-01-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Goodridge HS;Shimada T;Wolf AJ;Hsu YM;Becker CA;Lin X;Underhill DM
通讯作者：
Underhill DM