BDNF val66met polymorphism affects aging of multiple types of memory.
BDNF val66met polymorphism affects aging of multiple types of memory.
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DOI：
10.1016/j.brainres.2014.09.044
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发表时间：
2015-07-01
期刊：
影响因子：
2.9
通讯作者：
Rodrigue, Karen M.
中科院分区：
文献类型：
--
作者：
Kennedy, Kristen M.;Reese, Elizabeth D.;Horn, Marci M.;Sizemore, April N.;Unni, Asha K.;Meerbrey, Michael E.;Kalich, Allan G., Jr.;Rodrigue, Karen M.
关键词：
BDNFVal66Met多态(Rs6265)影响突触中脑源性神经营养因子的活性依赖性分泌，而突触对学习和记忆至关重要。与Val纯合子相比，Met等位基因纯合子或杂合子个体的BDNF分泌量较低，可能存在陈述性记忆表现下降的风险，但尚不清楚哪些类型的陈述性记忆可能受到影响，以及BDNF Val66Met多态如何影响一生中的记忆老化。这项横断面研究调查了116名20-93岁健康成年人的脑源性神经营养因子基因多态性对多项记忆指标(项目、联想、预期、主观抱怨)的影响。年龄增长对项目记忆、联想记忆和前瞻记忆有负向影响，但对主观记忆主诉无显著影响。对于项目记忆和前瞻记忆，存在显著的年龄x BDNF组交互作用，表明BDNF MET携带者的年龄对整个寿命的记忆表现的负面影响比Val纯合子要强得多。BDNF MET携带者还认可了明显更多的主观记忆抱怨，无论年龄大小，并显示出与Val纯合子相比，联想记忆表现更差的趋势(p<；0.07)。这些结果表明，脑源性神经营养因子的遗传易感性通过BDNF Val66Met多态对情景记忆的多个指数产生影响--在某些情况下，所有个体不分年龄(主观记忆和联想记忆)，在另一些情况下，加剧了与年龄相关的记忆差异(项目记忆和前瞻性记忆)。
The BDNF val66met polymorphism (rs6265) influences activity-dependent secretion of brain-derived neurotrophic factor in the synapse, which is crucial for learning and memory. Individuals homozygous or heterozygous for the met allele have lower BDNF secretion than val homozygotes and may be at risk for reduced declarative memory performance, but it remains unclear which types of declarative memory may be affected and how aging of memory across the lifespan is impacted by the BDNF val66met polymorphism. This cross-sectional study investigated the effects of BDNF polymorphism on multiple indices of memory (item, associative, prospective, subjective complaints) in a lifespan sample of 116 healthy adults aged 20-93 years. Advancing age showed a negative effect on item, associative and prospective memory, but not on subjective memory complaints. For item and prospective memory, there were significant age x BDNF group interactions, indicating the adverse effect of age on memory performance across the lifespan was much stronger in the BDNF met carriers than for the val homozygotes. BDNF met carriers also endorsed significantly greater subjective memory complaints, regardless of age, and showed a trend (p < .07) toward poorer associative memory performance compared to val homozygotes. These results suggest that genetic predisposition to the availability of brain-derived neurotrophic factor, by way of the BDNF val66met polymorphism, exerts an influence on multiple indices of episodic memory – in some cases in all individuals regardless of age (subjective memory and perhaps associative memory), in others as an exacerbation of age-related differences in memory across the lifespan (item and prospective memory).
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影响因子：
3.4
作者：
Banner, Harrison;Bhat, Venkataramana;Bohbot, Veronique D.
通讯作者：
Bohbot, Veronique D.
影响因子：
2.4
作者：
Chalfonte, BL;Johnson, MK
通讯作者：
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DOI：
10.1002/neu.480251107
发表时间：
1994-11-01
期刊：
JOURNAL OF NEUROBIOLOGY
影响因子：
--
作者：
BARBACID, M
通讯作者：
BARBACID, M
影响因子：
5.5
作者：
Cheeran, Binith;Talelli, Penelope;Rothwell, John C.
通讯作者：
Rothwell, John C.
影响因子：
2.9
作者：
Erickson KI;Kim JS;Suever BL;Voss MW;Francis BM;Kramer AF
通讯作者：
Kramer AF