Advancing Clinical Trials in Nursing Homes: A Proposed Roadmap to Success.
Advancing Clinical Trials in Nursing Homes: A Proposed Roadmap to Success.
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DOI：
10.1016/j.jamda.2021.11.034
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发表时间：
2022-03
影响因子：
7.6
通讯作者：
Zimmerman S
中科院分区：
文献类型：
--
作者：
Gurwitz JH;Quinn CC;Abi-Elias IH;Adams AS;Bartel R;Bonner A;Boxer R;Delude C;Gifford D;Hanson B;Ito K;Jain P;Magaziner JS;Mazor KM;Mitchell SL;Mody L;Nace D;Ouslander J;Reifsnyder J;Resnick B;Zimmerman S
在疗养院进行有效的临床研究以解决COVID-19的预防和治疗面临巨大挑战。在医疗保健系统研究网络-美国老年人独立中心老龄化倡议下，召集了一个多学科利益相关者咨询小组，以制定建议，提高美国养老院临床研究企业的能力。该小组将疗养院视为临床试验的环境，审查了疗养院临床试验的现状，并最终提出了建立一个集中支持和管理的疗养院临床试验研究网络的建议。本报告总结了专家组的建议，这些建议是根据以下核心原则制定的：酌情利用现有的研究基础设施;利用研究人员与养老院和养老院公司团体的现有生产伙伴关系;包括疗效和有效性临床试验;对广泛的利益攸关方，包括养老院居民及其护理伙伴作出反应;与广泛的临床和医疗保健提供研究问题相关;能够根据需要调整研究重点和环境;酌情为行业赞助的研究创造途径;投资于增加研究人群和研究人员多样性的战略;并促进下一代养老院研究人员的发展。
An effective clinical research effort in nursing homes to address prevention and treatment of COVID-19 faced overwhelming challenges. Under the Health Care Systems Research Network-Older Americans Independence Centers AGING Initiative, a multidisciplinary Stakeholder Advisory Panel was convened to develop recommendations to improve the capability of the clinical research enterprise in US nursing homes. The Panel considered the nursing home as a setting for clinical trials, reviewed the current state of clinical trials in nursing homes, and ultimately developed recommendations for the establishment of a nursing home clinical trials research network that would be centrally supported and administered. This report summarizes the Panel’s recommendations, which were developed in alignment with the following core principles: build on available research infrastructure where appropriate; leverage existing productive partnerships of researchers with groups of nursing homes and nursing home corporations; encompass both efficacy and effectiveness clinical trials; be responsive to a broad range of stakeholders including nursing home residents and their care partners; be relevant to an expansive range of clinical and health care delivery research questions; be able to pivot as necessary to changing research priorities and circumstances; create a pathway for industry-sponsored research as appropriate; invest in strategies to increase diversity in study populations and the research workforce; and foster the development of the next generation of nursing home researchers.
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影响因子：
6.3
作者：
Verdoorn BP;Evans TK;Hanson GJ;Zhu Y;Langhi Prata LGP;Pignolo RJ;Atkinson EJ;Wissler-Gerdes EO;Kuchel GA;Mannick JB;Kritchevsky SB;Khosla S;Rizza SA;Walston JD;Musi N;Lipsitz LA;Kiel DP;Yung R;LeBrasseur NK;Singh RJ;McCarthy T;Puskarich MA;Niedernhofer LJ;Robbins PD;Sorenson M;Tchkonia T;Kirkland JL
通讯作者：
Kirkland JL
DOI：
10.1001/jama.2021.88282021
发表时间：
2021-06-03
影响因子：
120.7
作者：
Cohen, Myron S.;Nirula, Ajay;Skovronsky, Daniel M.
通讯作者：
Skovronsky, Daniel M.
影响因子：
6.3
作者：
Tisminetzky M;Bayliss EA;Magaziner JS;Allore HG;Anzuoni K;Boyd CM;Gill TM;Go AS;Greenspan SL;Hanson LR;Hornbrook MC;Kitzman DW;Larson EB;Naylor MD;Shirley BE;Tai-Seale M;Teri L;Tinetti ME;Whitson HE;Gurwitz JH
通讯作者：
Gurwitz JH
影响因子：
6.3
作者：
Sierra, Felipe;Caspi, Avshalom;Fortinsky, Richard H.;Haynes, Laura;Lithgow, Gordon J.;Moffitt, Terrie E.;Olshansky, S. Jay;Perry, Daniel;Verdin, Eric;Kuchel, George A.
通讯作者：
Kuchel, George A.
DOI：
10.1111/j.1532-5415.1993.tb02055.x
发表时间：
1993-02-01
影响因子：
6.3
作者：
OUSLANDER, JG;SCHNELLE, JF
通讯作者：
SCHNELLE, JF