Moving geroscience from the bench to clinical care and health policy.
Moving geroscience from the bench to clinical care and health policy.
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DOI：
10.1111/jgs.17301
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发表时间：
2021-09
影响因子：
6.3
通讯作者：
Kuchel, George A.
中科院分区：
文献类型：
--
作者：
Sierra, Felipe;Caspi, Avshalom;Fortinsky, Richard H.;Haynes, Laura;Lithgow, Gordon J.;Moffitt, Terrie E.;Olshansky, S. Jay;Perry, Daniel;Verdin, Eric;Kuchel, George A.
老年病学家和其他人必须接受新兴的老年科学领域。直到最近，老年科学研究一直是在实验室动物中进行的，但现在这一领域需要专门的专业知识来照顾患有多种慢性疾病和老年综合征的脆弱老年患者，这些人群可能从新兴疗法中受益最多。虽然按时间顺序老化测量每个人都平等发生的时钟时间的不可避免的流逝，但生物老化因个体而异，重要的是，它是可以修改的。我们对生物衰老的理解的进步，改变其速度的策略的发现，以及对衰老作为慢性疾病的共同风险因素的认识，共同导致了老年科学假说。这一假说指出，干预修改老化生物学可以减缓其进展，从而延迟或预防多种疾病和障碍的发作。在这里，我们希望报告2019年11月4日至5日在美国国立卫生研究院举行的第三届老年科学峰会，该峰会强调了参与包括临床医生在内的其他学科的重要性。迫切需要在临床试验，健康结果研究，行为和社会科学，卫生政策和经济学方面具有专业知识的科学家的参与，以将老年科学的发现从实验室转化为临床护理和卫生政策。生物老化作为COVID-19最重要的可改变因素之一的出现，加上我们的社会在面对这些类型的公共卫生紧急情况时无法再次认识和应对老龄化作为优先事项和机会，这增加了扩大这一老年科学联盟的紧迫性。
Geriatricians and others must embrace the emerging field of geroscience. Until recently geroscience research was pursued in laboratory animals, but now this field requires specialized expertise in the care of vulnerable older patients with multiple chronic diseases and geriatric syndromes, the population likely to benefit the most from emerging therapies. While chronological aging measures the inevitable passage of clock time that occurs equally for everyone, biological aging varies among individuals, and importantly, it is modifiable. Advances in our understanding of biological aging, the discovery of strategies for modifying its rate, and an appreciation of aging as a shared risk factor for chronic diseases have jointly led to the Geroscience Hypothesis. This hypothesis states that interventions modifying aging biology can slow its progression—resulting in the delay or prevention of the onset of multiple diseases and disorders. Here we wish to report on the Third Geroscience Summit held at National Institutes of Health on November 4–5, 2019, which highlighted the importance of engaging other disciplines including clinicians. Involvement by scientists with expertise in clinical trials, health outcomes research, behavioral and social sciences, health policy, and economics is urgently needed to translate geroscience discoveries from the bench to clinical care and health policy. Adding to the urgency of broadening this geroscience coalition is the emergence of biological aging as one the most important modifiable factors of COVID-19, combined with the inability of our society to once again recognize and confront aging as a priority and opportunity when facing these types of public health emergencies.
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影响因子：
7.8
作者：
Harrison DE;Strong R;Allison DB;Ames BN;Astle CM;Atamna H;Fernandez E;Flurkey K;Javors MA;Nadon NL;Nelson JF;Pletcher S;Simpkins JW;Smith D;Wilkinson JE;Miller RA
通讯作者：
Miller RA
DOI：
10.1111/nyas.13297
发表时间：
2016-01-01
期刊：
ANNALS REPORTS, VOL 1386
影响因子：
--
作者：
Kohanski, Ronald A.;Deeks, Steven G.;Sierra, Felipe
通讯作者：
Sierra, Felipe
影响因子：
17.1
作者：
Kaeberlein, Matt;Galvan, Veronica
通讯作者：
Galvan, Veronica
影响因子：
29
作者：
Barzilai N;Crandall JP;Kritchevsky SB;Espeland MA
通讯作者：
Espeland MA
影响因子：
64.5
作者：
Kennedy BK;Berger SL;Brunet A;Campisi J;Cuervo AM;Epel ES;Franceschi C;Lithgow GJ;Morimoto RI;Pessin JE;Rando TA;Richardson A;Schadt EE;Wyss-Coray T;Sierra F
通讯作者：
Sierra F