Mouse oocyte control of granulosa cell development and function: paracrine regulation of cumulus cell metabolism.
Mouse oocyte control of granulosa cell development and function: paracrine regulation of cumulus cell metabolism.
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DOI：
10.1055/s-0028-1108008
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发表时间：
2009-01
影响因子：
2.7
通讯作者：
Eppig JJ
中科院分区：
文献类型：
--
作者：
Su YQ;Sugiura K;Eppig JJ
卵母细胞和伴随颗粒细胞之间的双向通讯对于两个区室的发育和功能至关重要。卵母细胞缺乏运输某些氨基酸以及进行糖酵解和胆固醇生物合成的能力，需要卵丘细胞为它们提供特定的氨基酸和这些代谢途径中的产物。卵母细胞通过促进卵母细胞中编码特定氨基酸转运蛋白和卵母细胞缺乏的代谢过程所必需的酶的基因的表达来控制卵丘细胞的代谢活动。因此，卵母细胞将代谢功能外包给卵丘细胞以补偿卵母细胞代谢缺陷。卵母细胞对颗粒细胞代谢的控制也可能与内分泌、旁分泌和自分泌信号协调参与调节卵泡发育速率。卵母细胞主要通过分泌旁分泌因子影响颗粒细胞发育，尽管近分泌信号也可能参与其中。卵母细胞来源的关键旁氨酸因子包括生长分化因子 9 (GDF9)、骨形态发生蛋白 15 (BMP15) 15 和成纤维细胞生长因子 8B (FGF8B)。
Bi-directional communication between oocytes and the companion granulosa cells is essential for the development and functions of both compartments. Oocytes are deficient in their ability to transport certain amino acids and in carrying out glycolysis and cholesterol biosynthesis, and require that cumulus cells provide them with the specific amino acids and the products in these metabolic pathways. Oocytes control metabolic activities in cumulus cells by promoting the expression of genes in cumulus cells encoding specific amino acid transporters and enzymes essential for the oocyte-deficient metabolic processes. Hence, oocytes outsource metabolic functions to cumulus cells to compensate for oocyte metabolic deficiencies. Oocyte control of granulosa cell metabolism may also participate in regulating the rate of follicular development in coordination with endocrine, paracrine and autocrine signals. Oocytes influence granulosa cell development mainly by secretion of paracrine factors although juxtacrine signals probably also participate. Key oocyte-derived paracine factors include growth differentiation factor 9 (GDF9), bone morphogenetic protein 15 (BMP15) 15, and fibroblast growth factor 8B (FGF8B).
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影响因子：
4.8
作者：
Bodin, Loys;Di Pasquale, Elisa;Mulsant, Philippe
通讯作者：
Mulsant, Philippe
影响因子：
3.6
作者：
Eppig, JJ;Pendola, FL;Pendola, JK
通讯作者：
Pendola, JK
影响因子：
2.7
作者：
Diaz, F. J.;Wigglesworth, K.;Eppig, J. J.
通讯作者：
Eppig, J. J.
DOI：
10.1083/jcb.71.2.680
发表时间：
1976-11
期刊：
The Journal of cell biology
影响因子：
--
作者：
Anderson E;Albertini DF
通讯作者：
Albertini DF
影响因子：
2.7
作者：
BUCCIONE, R;VANDERHYDEN, BC;EPPIG, JJ
通讯作者：
EPPIG, JJ