Genetic alterations in hepatocellular carcinomas: association between loss of chromosome 4q and p53 gene mutations.
Genetic alterations in hepatocellular carcinomas: association between loss of chromosome 4q and p53 gene mutations.
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DOI：
10.1038/sj.bjc.6690321
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发表时间：
1999-04
影响因子：
8.8
通讯作者：
Groopman, JD
中科院分区：
文献类型：
--
作者：
Rashid, A;Wang, JS;Qian, GS;Lu, BX;Hamilton, SR;Groopman, JD
肝细胞癌（HCC）高发区的主要危险因素包括B和丙型肝炎病毒（HBV、HCV）感染和黄曲霉毒素暴露。本文对上海和启东地区24例肝切除标本的遗传学改变进行了研究。B型肝炎病毒整合在所有患者样本中，63%的患者存在GSTM 1酶的无效表型。95%（23/24）的病例中存在p53改变：12例HCC中p53基因突变，13例p53过表达，17例染色体17 p杂合性丢失（洛）。启东地区所有7例p53突变的肝癌和上海地区5例p53突变的肝癌中的3例都有黄曲霉毒素相关的点突变，即密码子249第3位G到T的颠换。HCC无微卫星不稳定性。染色体4 q、1 p、16 q和13 q的洛分别为50%、46%、42%和38%，且4 q在含有p53突变的HCC中优先丢失：75%（9/12）的HCC中存在4 q的洛，而无p53基因突变的HCC中仅25%（3/12）存在4 q的LOH（P = 0.01）。提示p53基因突变与4 q缺失在肝癌发病中可能存在相互作用。© 1999癌症研究运动
The major risk factors for hepatocellular carcinomas (HCC) in high incidence areas include infection with hepatitis B and C viruses (HBV, HCV) and exposure to aflatoxin. Genetic alterations in 24 liver resection specimens from Shanghai and Qidong were studied. Hepatitis B virus was integrated in all patient samples, and a null phenotype for the GSTM1 enzyme was present in 63% of patients. Alteration of p53 was present in 95% (23/24) of cases: mutations of the p53 gene in 12 HCC, p53 overexpression in 13 and loss of heterozygosity (LOH) of chromosome 17p in 17. All seven HCCs with a p53 mutation from Qidong and three of five from Shanghai had the aflatoxin-associated point mutation with a G to T transversion at codon 249, position 3. No HCC had microsatellite instability. LOH of chromosome 4q, 1p, 16q and 13q was present in 50%, 46%, 42% and 38%, respectively, and 4q was preferentially lost in HCCs containing a p53 mutation: LOH of 4q was present in 75% (9/12) of HCC with, but only 25% (3/12) of HCC without, a p53 gene mutation (P = 0.01). These data indicate a possible interaction between p53 gene mutation and 4q loss in the pathogenesis of HCC. © 1999 Cancer Research Campaign
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影响因子：
8.8
作者：
Gleeson, C M;Sloan, J M;McGuigan, J A;Ritchie, A J;Weber, J L;Russell, S E
通讯作者：
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发表时间：
1989-06-01
影响因子：
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作者：
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影响因子：
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作者：
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