Extracellular matrix signaling in morphogenesis and repair.

Extracellular matrix signaling in morphogenesis and repair.
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DOI:
10.1016/j.copbio.2013.04.011
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发表时间:
2013-10
影响因子:
7.7
通讯作者:
Barker, Thomas H.
Barker, Thomas H.
中科院分区:
工程技术1区
文献类型:
--
作者:
Clause, Kelly C.;Barker, Thomas H.

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细胞外基质(ECM)对于许多细胞过程包括生长、分化、存活和形态发生是至关重要的。细胞通过降解和重组ECM来重塑和重塑ECM,在塑造周围环境和指导自身表型方面发挥积极作用。机械和生物化学分子以多种方式影响ECM动力学;通过释放小的生物活性信号分子,释放储存在ECM内的生长因子,引发暴露隐蔽位点的基质蛋白的结构变化,以及通过直接降解基质蛋白。细胞和ECM之间的动态相互通信在组织发育、稳态和伤口愈合中起着重要作用。
The extracellular matrix (ECM) is critically important for many cellular processes including growth, differentiation, survival, and morphogenesis. Cells remodel and reshape the ECM by degrading and reassembling it, playing an active role in sculpting their surrounding environment and directing their own phenotypes. Both mechanical and biochemical molecules influence ECM dynamics in multiple ways; by releasing small bioactive signaling molecules, releasing growth factors stored within the ECM, eliciting structural changes to matrix proteins which expose cryptic sites and by degrading matrix proteins directly. The dynamic reciprocal communication between cells and the ECM plays a fundamental roll in tissue development, homeostasis, and wound healing.
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