TCPs, WUSs, and WINDs: families of transcription factors that regulate shoot meristem formation, stem cell maintenance, and somatic cell differentiation.
TCPs, WUSs, and WINDs: families of transcription factors that regulate shoot meristem formation, stem cell maintenance, and somatic cell differentiation.
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DOI：
10.3389/fpls.2014.00427
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发表时间：
2014
影响因子：
5.6
通讯作者：
Ohme-Takagi M
中科院分区：
文献类型：
--
作者：
Ikeda M;Ohme-Takagi M
与不能改变其命运的体细胞哺乳动物细胞相反，植物细胞可以去分化以形成全能愈伤组织细胞并在用特定植物激素处理后再生整个植物。然而，在植物中，控制分化-去分化和细胞全能性的调控机制和关键因素尚未完全阐明。最近，已经鉴定了几种调节分生组织形成和去分化的植物转录因子，包括TEOSINTE BRANCHED 1/CYCLOIDEA/PROLIFERATING CELL FACTOR（TCP）、WUSCHEL（WUS）和WOUND INDUCED DEDIFFERENTIATION（WIND 1）家族的成员。有趣的是，TCP是一个转录激活子，它作为一个负调节子的茎分生组织的形成，而WUS是一个转录抑制子，它积极地维持茎分生组织的干细胞的全能性。我们在这里描述TCP，WUS和WIND转录因子的功能，在调节分化-去分化的正和负转录调节。
In contrast to somatic mammalian cells, which cannot alter their fate, plant cells can dedifferentiate to form totipotent callus cells and regenerate a whole plant, following treatment with specific phytohormones. However, the regulatory mechanisms and key factors that control differentiation-dedifferentiation and cell totipotency have not been completely clarified in plants. Recently, several plant transcription factors that regulate meristem formation and dedifferentiation have been identified and include members of the TEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR (TCP), WUSCHEL (WUS), and WOUND INDUCED DEDIFFERENTIATION (WIND1) families. WUS and WIND positively control plant cell totipotency, while TCP negatively controls it. Interestingly, TCP is a transcriptional activator that acts as a negative regulator of shoot meristem formation, and WUS is a transcriptional repressor that positively maintains totipotency of the stem cells of the shoot meristem. We describe here the functions of TCP, WUS, and WIND transcription factors in the regulation of differentiation-dedifferentiation by positive and negative transcriptional regulators.
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