CASE-CONTROL STUDY OF LUNG CANCER RISK FROM RESIDENTIAL RADON EXPOSURE IN WORCESTER COUNTY, MASSACHUSETTS
CASE-CONTROL STUDY OF LUNG CANCER RISK FROM RESIDENTIAL RADON EXPOSURE IN WORCESTER COUNTY, MASSACHUSETTS
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马萨诸塞州伍斯特县住宅氡暴露导致肺癌风险的病例对照研究
DOI：
10.1097/01.hp.0000288561.53790.5f
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发表时间：
2008
期刊：
影响因子：
2.2
通讯作者：
Zenaida Popkin
中科院分区：
文献类型：
--
作者：
R. Thompson;Donald F. Nelson;J. Popkin;Zenaida Popkin
对200例(男58%，女42%)居民氡暴露及其放射性子体所致肺癌风险进行了研究，并与397例年龄、性别相匹配的对照组进行了比较。重点放在使用蚀刻跟踪探测器进行准确和广泛的长达一年的剂量测量，同时仔细询问家庭活动的历史模式。在控制居住年限、吸烟、教育程度、收入和工作接触已知或潜在致癌物年限的同时，条件Logistic回归被用来模拟氡暴露对癌症结果的影响。吸烟分为九类：从不吸烟者、四类现在吸烟者和四类既往吸烟者。氡暴露分为6类(模型1)，中断点分别为25、50、75、150和250Bq m−3，其中最低的作为参考。令人惊讶的是，调整后的优势比(AOR)依次为1.00、0.53、0.31、0.47、0.22和2.50，其中第三类显著低于1.0(p<；0.05)，第二、第四和第五类接近统计学意义(p<；0.1)。使用自然三次样条法的替代分析(模型2)允许计算作为氡暴露的连续函数的AORS。这一分析得出的AOR显著小于1.0，在大约85到123Bq m≤3之间具有边缘统计学意义(0.048，≤p≤0.05)。与高中辍学的受试者相比，在控制了吸烟、住院年限和工作暴露后，受过大学教育的受试者患癌症的风险显著降低，AOR=0.3(95%CI：0.13，0.69)，p=0.005(模型1)。
A study of lung cancer risk from residential radon exposure and its radioactive progeny was performed with 200 cases (58% male, 42% female) and 397 controls matched on age and sex, all from the same health maintenance organization. Emphasis was placed on accurate and extensive year-long dosimetry with etch-track detectors in conjunction with careful questioning about historic patterns of in-home mobility. Conditional logistic regression was used to model the outcome of cancer on radon exposure, while controlling for years of residency, smoking, education, income, and years of job exposure to known or potential carcinogens. Smoking was accounted for by nine categories: never smokers, four categories of current smokers, and four categories of former smokers. Radon exposure was divided into six categories (model 1) with break points at 25, 50, 75, 150, and 250 Bq m−3, the lowest being the reference. Surprisingly, the adjusted odds ratios (AORs) were, in order, 1.00, 0.53, 0.31, 0.47, 0.22, and 2.50 with the third category significantly below 1.0 (p < 0.05), and the second, fourth, and fifth categories approaching statistical significance (p < 0.1). An alternate analysis (model 2) using natural cubic splines allowed calculating AORs as a continuous function of radon exposure. That analysis produces AORs that are substantially less than 1.0 with borderline statistical significance (0.048 ≤ p ≤ 0.05) between approximately 85 and 123 Bq m−3. College-educated subjects in comparison to high-school dropouts have a significant reduction in cancer risk after controlling for smoking, years of residency, and job exposures with AOR = 0.30 (95% CI: 0.13, 0.69), p = 0.005 (model 1).
影响因子：
5
作者：
W. Field;D. Steck;Brian J. Smith;C. Brus;E. L. Fisher;J. Neuberger;Charles E. PIatz;Robert A. Robinson;R. Woolson;Charles F. Lynch
通讯作者：
W. Field;D. Steck;Brian J. Smith;C. Brus;E. L. Fisher;J. Neuberger;Charles E. PIatz;Robert A. Robinson;R. Woolson;Charles F. Lynch
DOI：
10.1016/s0027-5107(02)00068-4
发表时间：
2002-06-19
影响因子：
2.3
作者：
Iyer, R;Lehnert, BE
通讯作者：
Lehnert, BE