A role for IL‐4 in immunologically mediated enteropathy
A role for IL‐4 in immunologically mediated enteropathy
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IL-4 在免疫介导的肠病中的作用
DOI：
10.1111/j.1365-2249.1995.tb03473.x
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发表时间：
1995
影响因子：
4.6
通讯作者：
M. Widmer
中科院分区：
文献类型：
--
作者：
A. Mowat;M. Widmer
许多临床肠病与局部细胞免疫(CMI)反应有关，实验证据表明细胞因子与肠道病理有关。我们在这里表明，用单抗或IL-4受体(IL-4R)的可溶性形式去除IL-4可以防止以隐窝增生和上皮内淋巴细胞(IEL)募集为特征的增殖型小鼠移植物抗宿主反应(GVHR)的空肠表现。在GVHR破坏性模型中，去除IL-4不能阻止绒毛萎缩的出现，也不影响系统免疫的任何指标。这些结果表明，IL-4可能在肠道免疫病理的增殖性方面发挥选择性作用，并提示该细胞因子可能为免疫治疗提供一个有用的靶点。
A number of clinical enteropathies are associated with a local cell‐mediated immune (CMI) response, and experimental evidence indicates that cytokines are responsible for the intestinal pathology. We show here that depletion of IL‐4 using MoAb or a soluble form of the IL‐4 receptor (IL‐4R) prevents the jejunal manifestations of a proliferative form of murine graft‐versus‐host reaction (GVHR) characterized by crypt hyperplasia and recruitment of intraepithelial lymphocytes (IEL). Depletion of IL‐4 did not prevent the appearance of villus atrophy in a destructive model of GVHR, and had no effect on any indices of systemic immunity. These results indicate that IL‐4 may play a selective role in mediating proliferative aspects of intestinal immunopathology, and suggest that this cytokine may provide a useful target for immunotherapy.
影响因子：
20.3
作者：
P. McCarthy;S. Abhyankar;S. Neben;Gale D. Newman;C. Sieff;R. Thompson;Steven;-J.;Burakoff
通讯作者：
P. McCarthy;S. Abhyankar;S. Neben;Gale D. Newman;C. Sieff;R. Thompson;Steven;-J.;Burakoff
DOI：
--
发表时间：
1993
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Ballas,ZK;Rasmussen,W
通讯作者：
Rasmussen,W