HEPATITIS C VIRUS ANTIBODIES AMONG RISK GROUPS IN SPAIN
HEPATITIS C VIRUS ANTIBODIES AMONG RISK GROUPS IN SPAIN
复制标题
西班牙高危人群中的丙型肝炎病毒抗体
DOI：
10.1016/s0140-6736(89)90485-6
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
G. Kuo
中科院分区：
文献类型：
--
作者：
J. Esteban;L. Viladomiu;António Gonzalez;M. Roget;J. Genescà;R. Esteban;J. López;Hernández Jm;V. Vargas;M. Buti;J. Guàrdia;M. Houghton;Q. Choo;G. Kuo
西班牙丙型肝炎病毒(丙型肝炎病毒)感染的频率是通过一种基于血清抗丙型肝炎病毒抗体的重组免疫分析方法来评估的。根据血液传播病毒感染和存在肝病的风险选择了676名患者，对836份血清样本进行了检测。在感染高危患者(有或无肝病)中，85%的前瞻性随访患者为输血后非甲、非乙肝患者，62%的慢性肝炎或肝硬变患者和有输血史的患者，70%的血友病患者接受替代治疗，70%的静脉吸毒者和20%的血液透析患者。感染人类免疫缺陷病毒的男同性恋者中仅有8%呈阳性，与吸毒者有女性接触者中仅6%呈阳性。在有肝病且无肠外接触血液病史的患者中，38%的隐源性、酒精性或原发性胆汁性肝硬变患者和44%的慢性活动性肝炎患者检测到抗丙型肝炎抗体。在无肝炎危险因素的健康受试者中，抗-丙型肝炎的总感染率为1.2%。
The frequency of hepatitis C virus (HCV) infection in Spain was assessed by means of a recombinant-based immunoassay for serum anti-HCV antibodies. 836 serum samples were tested from 676 patients selected according to their risk of blood-borne viral infections and presence of liver disease. Among patients at high risk of infection (with or without liver disease) anti-HCV antibodies were found in 85% of prospectively followed patients with post-transfusion non-A, non-B hepatitis, 62% of patients with chronic hepatitis or cirrhosis and a history of blood transfusion, 70% of haemophiliacs receiving replacement therapy, 70% of intravenous drug abusers, and 20% of haemodialysis patients. Only 8% of homosexual men infected with human immunodeficiency virus and 6% of female contacts of drug abusers were positive. Among patients with liver disease and no history of parenteral exposure to blood, anti-HCV antibodies were detected in 38% with cryptogenic, alcoholic, or primary biliary cirrhosis and in 44% with chronic active hepatitis. Among healthy subjects without risk factors for hepatitis the overall prevalence of anti-HCV was 1·2%.
影响因子：
6.4
作者：
ALTER, MJ;GERETY, RJ;MATANOSKI, GM
通讯作者：
MATANOSKI, GM